Publications related to the work of our SBRP will be listed here as they become available. An asterisk (*) identifies formal collaborative publications involving more than one project and/or core. Brown University's SBRP members also maintain listings of their publications on departmental pages. To view these listings, use the links marked "departmental page" on the Investigators page of this website.

PROJECT 1: Mechanism of Toxicant-induced Testicular Sensitization
Kim Boekelheide, M.D., Ph.D.

2008

Bryant, B.H., Yamasaki, H., Sandrof, M., Boekelheide, K. Spermatid head retention as a marker of 2,5-hexanedione-induced testicular toxicity in the rat. Toxicol. Pathol., in press.

Klysik, J., Theroux, S.J., Sedivy, J.M., Moffit, J.S., Boekelheide, K. Signaling crossroads: The function of Raf kinase inhibitory protein in cancer, the central nervous system and reproduction. Cell Signal. 20:1-9, 2008.

2007

Boekelheide, K. Toxicological Highlight — Mixed Messages. Toxicol. Sci. 99:1-2, 2007.

Bryant, B.H., Boekelheide, K. Time-dependent changes in post-mortem testis histopathology in the rat. Toxicol. Pathol. 35:665-71, 2007.

Moffit, J.S., Boekelheide, K., Sedivy, J.M., Klysik, J. Mice lacking Raf kinase Inhibitor Protein-1 (RKIP-1) have altered sperm capacitation and reduced reproduction rates with a normal response to testicular injury. J. Androl. 28:883-90, 2007.

Moffit, J.S., Bryant, B.H., Hall, S.J., Boekelheide K. Dose-dependent effects of Sertoli cell toxicants 2,5-hexanedione, carbendazim, and mono-(2-ethylhexyl) phthalate in adult rat testis. Toxicologic Pathol. 35:719-27, 2007.

Rasoulpour, R.J., Boekelheide, K. NF-?B activation elicited by ionizing radiation is pro-apoptotic in testis. Biol. Reprod. 76:279-85, 2007.

2006

Rasoulpour, R.J., Boekelheide, K. The Sycp-1Cre transgenic mouse and male germ cell inhibition of NF-?B. J. Androl. 27:729-733, 2006.

2008

*Kane, A.B., Hurt, R.H. Nanotoxicology: the Asbestos Analogy Revisited. Nature Nanotechnology 3: 378-379, 2008.

*Guo, L., Von Dem Bussche, A., Buechner, M., Kane, A.B., Hurt, R.H. Adsorption of essential micronutrients by carbon nanotubes and its implications for nanotoxicity testing, Small 4: 721-727, 2008.

*Liu, X., Guo, L., Morris, D., Kane, A.B., Hurt, R.H. Targeted removal of bioavailable metal as a detoxification strategy for carbon nanotubes. Carbon 46: 489-500, 2008.

2007

*Guo, L., Liu, X., Sanchez, V., Vaslet, C., Kane, A.B., Hurt, R.H. A window of opportunity: Designing carbon nanomaterials for environmental safety and health. Mater. Sci. Forum 544/545:511-516, 2007.

*Guo, L., Morris, D.G., Liu, X., Vaslet C., Hurt, R.H., Kane, A.B. Iron bioavailability and redox activity in diverse carbon nanotube samples. Chem. Mater. 19:3472-78, 2007.

*Liu, X., Gural, V., Morris, D., Murray, D., Zhitkovich, A., Kane, A.B., Hurt, R.H.G Bioavailability of nickel in single-wall carbon nanotubes. Adv. Mater. 19:2790-96, 2007.

Pietruska, J.R., Kane, A.B. SV40 oncoproteins enhance asbestos-induced dna double-strand breaks and abrogate senescence in murine mesothelial cells. Cancer Res. 67: 3637-45, 2007.

*Yan, A., Von Dem Bussche, A., Kane, A.B., Hurt, R.H. Tocopheryl polyethylene glycol succinate as a safe, antioxidant surfactant for processing carbon nanotubes and fullerenes. Carbon 45:2463-70, 2007.

2006

*Hurt, R.H., Monthioux, M., Kane, A.B. Toxicology of carbon nanomaterials: status, trends, and perspectives on the special issue. Carbon 44:1028-33, 2006.

*Yan, A., Lau, B.W., Weissman, B.S., Külaots, I., Yang, N.Y.C., Kane,A.B., Hurt, R.B. Biocompatible hydrophilic supramolecular carbon nanoparticles for cell delivery. Adv. Mater. 18:2373-78, 2006.

2009

Tewari, N., Kalkunte S., Murray, D. W., Sharma, S. The water channel aquaporin 1 is a novel target of polychlorinated biphenyls for in utero anomalies. J. Biol. Chem., 284: 15224-15232, 2009.

2008

Kalkunte, S., Chichester, C., Sentman, C., Romero, R., Sharma, S. Evolution of non-cytotoxic uterine Natural Killer (uNK) cells. Am J Reprod Immunol, in press.

Abrahams, V. M., Aldo, P., Murphy, S. P., Visintin, I., Romero, R., Sharma, S., Mor, G. TLR6 protects trophoblast cells from TLR2/TLR1-mediated apoptosis. J Immunol, in press.

Gotsch, F., Romero, R., Kusanovic, J. P., Erez, O., Espinoza, J., Kim, C. J., Vaisbuch, E., Than, G. N., Mazaki-Tovi, S., Chaiworapongsa, T., Mazor, M., Bo Yoon, B. H., Edwin, S., Gomez, R., Mittal, P., Hassan, S., Sharma, S. The anti-inflammatory limb of the immune response in preterm labor, intra-amniotic infection/inflammation and spontaneous parturition at term: A role for Interleukin-10. J Mat-Fet Neonat Med, in press.

Gustafsson, C., Matussek, A., Geffers, R., Matthiesen, L., Berg, G., Sharma, S., Buer, J., Ernerudh, J. Gene expression profiling of human decidual macrophages: Evidence for immunosuppressive phenotype. PLoS ONE, in press.

Tewari, N., Kalkunte, S., Thaxton, J., Sharma, S. Polychlorinated biphenyls (PCBs) and female reproductive health: An enigmatic paradigm. ISSRF Proceedings, in press.

Lee, H-S., Wang, Y., Maciejewski, B. S., Esho, K., Fulton, C., Sharma, S., Sanchez-Estaban, J. Interleukin-10 Protects cultured fetal rat type II epithelial cells from injury induced by mechanical stretch. Am J Physiol (Lung Cell Mol Physiol) 294, in press.

2007

Mondeesterin-Sorrentino, M., Smulian, J. N., Vintzileos, A. M., Sorrentino, D., Ananth, C. V., Sharma, S., Hanna, N. N. Variations in cervical and vaginal IL-10 and IL-8 concentrations throughout gestation in normal pregnancies. Am J Reprod Immunol 57: 482-487, 2007.

Than, N.G., Paidas, M.J., Mizutani, S., Sharma, S., Padbury, J., Barnea, E. R. Embryo-placento-maternal interaction and biomarkers: From diagnosis to therapy. Placenta, 21:s107-s110, 2007.

2006

Sharma, S., Murphy, S., Barnea, E. Genes regulating implantation and fetal development: A focus on mouse knockout models. Frontiers Bioscience 11: 2123-37, 2006.

Tewari, N., Murphy, S.P., Sharma, S. Genetic stress (IL-10 deficiency) and toxicant (PCB)-induced disruption of pregnancy. Am. J. Reprod. Immunol. 55:408, 2006.

2005

Hanna, N., Bonifacio, L., Weinberger, B., Reddy, P., Murphy, S., Romero, R., Sharma, S. Evidence for Interleukin-10-mediated inhibition of cyclooxygenase-2 expression and prostaglandin production in preterm human placenta. Am. J. Reprod. Immunol. 55:19-27, 2005.

Murphy, S., Fast, L., Hanna, N., Sharma, S. Uterine NK cells mediate inflammation induced fetal demise in IL-10-null mice. J. Immunol. 175: 4084-90, 2005.

De Paepe, M. E., Mao, Q., Chao, Y., Powell, J. L., Rubin, L. P., Sharma, S. Hyperoxia-induced apoptosis and Fas/FasL expression in lung epithelial cells. Am J Physiol (Lung Cell Mol Physiol) 289: L647-659, 2005.

Clybouw, C., McHichi, B., Mouhamad, S., Auffredou, M., Bourgeade, M., Sharma, S., Vazquez, A. EBV infection of human B lymphocytes leads to down-regulation of Bim expression: relationship to resistance to apoptosis. J Immunol 175: 2968-2973, 2005.

2008

Branco R., Chung A.P., Jonhston T., Gurel V., Morais P., Zhitkovich A. The chromate-inducible chrBACF operon from the transposable element TnOtChr confers resistance to chromium(VI) and superoxide. J. Bacteriol., in press. Sep 5. [Epub ahead of print] PMID: 18776016

Guttmann D., Poage G., Johnston T.,Zhitkovich A. Reduction with glutathione is a weakly mutagenic pathway in chromium(VI) metabolism. Chem. Res. Toxicol., in press. Sep 23. [Epub ahead of print] PMID: 18808157

Reynolds M., Zhitkovich A. Ascorbate-mediated toxicity of hexavalent chromium in human cells. Metal Ions Biol. Med. 10, in press.

Salnikow K., Zhitkovich A. Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic and chromium. Chem. Res. Toxicol. 21: 28-44, 2008.

2007

*Liu, X., Gural, V., Morris, D., Murray, D., Zhitkovich, A., Kane, A.B., Hurt, R.H. Bioavailability of nickel in single-wall carbon nanotubes. Adv. Mater. 19: 2790-96, 2007.

Reynolds M., Zhitkovich, A. Cellular vitamin C increases chromate toxicity via a death program requiring mismatch repair but not p53. Carcinogenesis 28:1613-20, 2007.

Reynolds M., Stoddard L., Bespalov I., Zhitkovich A. Ascorbate acts as a highly potent inducer of chromate mutagenesis and clastogenesis: linkage to DNA breaks in G2 phase by mismatch repair. Nucleic Acids Res. 35:465-76, 2007.

2006

Karaczyn A., Ivanov S., Reynolds M., Zhitkovich A., Kasprzak K.S., Salnikow K. Ascorbate depletion mediates up-regulation of hypoxia-associated proteins by cell density and nickel. J. Cell. Biochem. 97:1025-35, 2006.

Messer J., Reynolds M., Stoddard L., Zhitkovich A. Causes of DNA single-strand breaks during reduction of chromate by glutathione in vitro and in cells. Free Radic. Biol. Med. 40:1981-92, 2006.

Quievryn, G., Messer, J., Zhitkovich A. Lower mutagenicity but higher stability of Cr-DNA adducts formed during gradual chromate activation with ascorbate. Carcinogenesis 27: 2316-21, 2006.

2008

Morallon-Nuñez, E., Arias-Pardilla, J., Calo, J.M., Cazorla-Amorós, D. Arsenic species interactions with a porous carbon electrode as determined with an electrochemical quartz crystal microbalance. Electrochimica Acta, in press.

2007

Bain, E., Calo, J.M. Porous materials for the adsorption/electrosorption of arsenic and chromium species from aqueous solutions. Am. Chem. Soc. Environ. Chem. Div. Preprints 47:211, 2007.

Yao, P., Calo, J.M., Hradil, G.I. Removal of metal mixtures from aqueous solutions with a spouted particulate electrode. Am. Chem. Soc. Environ. Chem. Div. Preprints 47:207, 2007.

2006

Gao, Y.-M., Calo, J.M., Hradil, G., Yao, P. Electrosorption/Electro-Desorption of Arsenic on an Activated Carbon in a Continuous Flow Cell. Proc. Carbon 2006, Paper No. SA477, Aberdeen, Scotland, 2006.

Shirvanian, P.A., Calo, J.M., Hradil, G.I. Numerical simulation of fluid-particle hydrodynamics in a rectangular spouted vessel. Int. J. Multiphase Flow 32:739-53, 2006.

2005

Shirvanian, P.A., Calo, J.M. Copper recovery in a particulate spouted bed electrode. J. Appl. Electrochem. 35:101-11, 2005.

2009

Lee, B., Sarin, L., Johnson, N.C., Hurt, R.H. A nano-selenium reactive barrier approach for managing mercury over the life-cycle of compact fluorescent lamps, Environmental Science and Technology, in press.

2008

Johnson, N., Manchester, S., Sarin, L., Gao, Y., Kulaots, I., Hurt, R.H. Mercury vapor release from broken compact fluorescent lamps and in situ capture by new nanomaterial sorbents, Environmental Science and Technology, in press.

*Guo, L., Von Dem Bussche, A., Buechner, M., Kane, A.B., Hurt, R.H. Adsorption of essential micronutrients by carbon nanotubes and its implications for nanotoxicity testing, Small, in press.

*Liu, X., Guo, L., Morris, D., Kane, A., Hurt, R.H. Targeted Removal of Bioavailable Metal as a Detoxification Strategy for Carbon Nanotubes, Carbon, 46(3) 489-500, 2008.

Manchester, S., Wang, X., Kulaots, I., Gao, Y., Hurt, R.H. High capacity mercury adsorption on freshly ozone-treated carbon surfaces, Carbon 46(3) 518-524, 2008.

2007

*Guo, L., Liu, X., Sanchez, V., Vaslet, C., Kane, A.B., Hurt, R.H. A window of opportunity: Designing carbon nanomaterials for environmental safety and health. Mater. Sci. Forum 544/545:511-516, 2007.

*Guo, L., Morris, D.G., Liu, X., Vaslet C., Hurt, R.H., Kane, A.B. Iron bioavailability and redox activity in diverse carbon nanotube samples. Chem. Mater. 19:3472-78, 2007.

Jian, K., Truong, T.C., Hoffman, W.P., Hurt, R.H. Mesoporous carbons with self-assembled surfaces of defined crystal orientation. Microporous Mesoporous Mater.,108 143-151, 2007.

*Liu, X., Gural, V., Morris, D., Murray, D., Zhitkovich, A., Kane, A.B., Hurt, R.H. Bioavailability of Nickel in Single-Wall Carbon Nanotubes. Adv. Mater. 19:2790–96, 2007.

*Yan, A., Von Dem Bussche, A., Kane, A.B., Hurt, R.H. Tocopheryl polyethylene glycol succinate as a safe, antioxidant surfactant for processing carbon nanotubes and fullerenes, Carbon 45:2463-70, 2007.

2006

*Hurt, R.H., Monthioux, M., Kane, A.B. Toxicology of Carbon Nanomaterials: Status, Trends, and Perspectives on the Special Issue. Carbon 44:1028-33, 2006.

*Yan, A., Lau, B.W., Weissman, B.S., Külaots, I., Yang, N.Y.C., Kane,A.B., Hurt, R.H. Biocompatible hydrophilic supramolecular carbon nanoparticles for cell delivery. Adv. Mater. 18:2373-78, 2006.

Jian K, Kulaots I, Yan A, Crawford GP, Hurt, R.H. Reconstruction and hydrophobicity of nanocarbon surfaces composed solely of graphene edges, Carbon, 44(10) 2102-2106, 2006.

2008

Goldfarb, J.L., Suuberg, E.M. Raoult's Law and its application to sublimation vapor pressures of mixtures of polycyclic aromatic hydrocarbons . Environ. Eng. Sci., December 2008.

Goldfarb, J.L., Suuberg, E.M. The effects of halogen hetero-atoms on the vapor pressures and thermodynamics of polycyclic aromatic compounds measured via the knudsen effusion technique. J. Chem. Thermodyn., in press, 2008 (available on line September, 2007).

Goldfarb, J.L., Suuberg, E.M. Vapor pressures and enthalpies of sublimation of ten polycyclic aromatic hydrocarbons determined via the knudsen effusion method. J. Chem. Eng. Data, in press, 2008 (available on line February 2008).

Goldfarb, J.L., Suuberg, E.M. Vapor pressures and thermodynamics of oxygen-containing polycyclic aromatic hydrocarbons measured using knudsen effusion. Environ. Toxicol. Chem., Vol. 27, No. 6, pp.1244–1249, 2008.

Goldfarb, J.L., Suuberg, E.M. Investigation of the Thermodynamic Ideality of Mixtures of Polycyclic Aromatic Hydrocarbons, Am. Chem. Soc. Div. Fuel Chem. Preprints, 2008.

2007

Goldfarb, J.L., Suuberg, E.M. The thermodynamic effects of adding heteroatoms to anthracene as measured by the Knudsen effusion technique. Am. Chem. Soc. Div. Fuel Chem. Preprints, 2007.

Goldfarb, J.L., Suuberg, E.M. Vapor pressures and enthalpies of sublimation of several polycyclic aromatic compounds as determined via the Knudsen effusion method. Am. Chem. Soc. Div. Fuel Chem. Preprints, 2007.

Goldfarb, J.L., Suuberg, E.M. Vapor pressures and thermodynamics of model mixtures of polycyclic aromatic compounds compared to Raoult’s law predictions. Am. Chem. Soc. Environ. Chem. Div. Preprints, 2007.

2006

Oja, V., Suuberg, E.M. Vapor pressures of coal tars and model aromatic systems. Am. Chem. Soc. Div. Fuel Chem. Preprints, 2006.

2007

*Bozkurt, O., Pennell, K.G., Suuberg, E.M. Evaluation of characterization techniques for vapor intrusion sites using a three-dimensional computational fluid dynamics (CFD) model. AWMA Vapor Intrusion Conference Proceedings Preprints, 2007.

*Bozkurt, O., Pennell, K.G., Suuberg, E.M. Evaluation of vapor intrusion potential using a three-dimensional computational fluid dynamics (CFD) Model. Am. Chem. Soc. Environ. Chem. Div. Preprints, 2007.

2009

Tewari, N., Kalkunte S., Murray, D. W., Sharma, S. The water channel aquaporin 1 is a novel target of polychlorinated biphenyls for in utero anomalies. J. Biol. Chem., 284: 15224-15232, 2009.

2007

*Liu, X., Gural, V., Morris, D., Murray, D., Zhitkovich, A., Kane, A.B., Hurt, R.H. Bioavailability of nickel in single-wall carbon nanotubes. Adv. Mater. 19: 2790-96, 2007.