Courses

Courses

Courses

Spring 2015

Human Physiology, (BIOL 2117)

Instructors: Professor John Stein
Course Location: Pfizer Inc. (Groton, CT Main Campus).
Time:
 Tuesdays, 3:00 - 6:00 PM.  Starting Jan 20, 2015

Course Description: BIOL 2117 provides an advanced introduction to many physiological systems.  After a quick review of fundamental concepts in diffusion, cell physiology, membrane potential and cell signaling, we will cover the endocrine, nervous, musculoskeletal, cardiovascular, respiratory, renal and gastrointestinal systems.  We will focus on normal human physiology and often times incorporate discussions of the pathophysiology of certain diseases.   Toward the end of the course we will cover the integrative topics of sports physiology, feeding behavior and diabetes.  The “special topic” at the end will be selected by the class from a list of options.

Core Curriculum Requirement: No

Syllabus:  http://bit.ly/1pa6nhP

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Fall 2014

Histology, (BIOL 1890)

Instructor: Professor Marjorie Thompson
Course Location: Pfizer Inc. (Groton, CT Main Campus). 
Time:  Wednesdays, 3:00 - 6:00 PM.  Classes start September 3, 2014.

Course Description:   This course will provide an in-depth treatment of the "stuff we are made of" and the wonderful logic of its organization.  The basic architecture of the body is of primary significance in gaining an understanding of what we as human animals are made of and how we work.  Fundamental to such an understanding is the basic unit of life, the cell.  During early development, cells in the aggregate undergo specialization as tissues which are the building blocks of the body.  This course focuses first on the biology of the four basic tissues (epithelium, connective tissue, muscle, and nerve) and second, how they contribute to the functional anatomy of all organs and systems.  We will emphasize characteristic developmental, structure-function and regulatory relationships - many of which are the foundation for the understanding of pathologic alteration.

Core Curriculum Requirement: No

Syllabus

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Spring 2014

Biology of the Eukaryotic Cell, (BIOL 2050)

Instructors: Professors Michael Foulk and Susan Gerbi
Course Location: Pfizer Inc. (Groton, CT Main Campus).
Time:
 Thursdays, 3:00 - 6:00 PM.

Course Description: This advanced course examines the organelles and macromolecular complexes of eukaryotic cells with respect to structural and functional roles in major cellular activities. It emphasizes the experimental basis for knowledge in modern cell biology using original literature, and discusses the validity of current concepts of cell structure and function.

Core Curriculum Requirement: Yes

Syllabus

 


Fall 2013

Virology, (BIOL 1560)

Instructor: Professor Peter Shank
Course Location: Pfizer, Inc. (Groton, CT Main Campus).
Time: Tuesdays, 3:00 - 6:00 PM.

Course Description: The emphasis of this course will be on understanding the molecular mechanisms of viral pathogenesis. It will begin with a general introduction to the field of virology and then focus on the biology of specific viruses that are associated with human disease. Lectures will be based on the current literature.

Core Curriculum Requirement: No

Syllabus


Spring 2013

Introduction to Epidemiologic Research Methods, (PHP 2120)

Instructors: Professors Elizabeth Triche and David Dore
Course Location: Pfizer, Inc. (Groton, CT Main Campus).
Time: Wednesdays, 3:00-6:00 PM.

Course Description: The overall objective of this course is to provide students with an introduction to epidemiologic research methods, with a focus on select topics in pharmacoepidemiology. We will discuss epidemiologic concepts in the context of drug studies that have led to increased public awareness and/or confusion (e.g., Vioxx, SSRI, aspirin, etc.). A common theme of the pharmacoepidemiology lectures will be the practice of epidemiology in highly regulated environments.

Core Curriculum Requirement: No

Syllabus


Fall 2012

Advanced Biochemistry, (BIOL 1270)

Instructor: Professor Gerwald Jogl
Course Location: Pfizer, Inc. (Groton, CT Main Campus).
Time: Thursdays, 4:00 - 6:30 PM.

Course Description: An advanced course in biochemistry, biochemical methods, and reading of the primary literature, featuring systematic coverage of the biochemistry of the central dogma, including DNA (replication, repair, recombination), RNA (regulation and mechanism of transcription, processing, turnover), and proteins structure, synthesis, modification, degradation, mechanisms of action, function).

The overall goal of this course is to study how essential concepts of biochemistry are applied in current biomedical research. We will review core topics of biochemistry and read one or two recent research articles relevant to these topics. The in-class discussion will (a) examine the experimental approach, (b) how the results of each report fit with prior knowledge, and (c) how these findings moved the field forward.

Core Curriculum Requirement: Yes

Syllabus


Spring 2012

Drug and Gene Delivery, (BIOL 2110)

Instructor: Professor Beth Zielinski
Course Location: Pfizer, Inc. (Groton, CT Main Campus).
Time: Wednesdays, 4:00 - 6:20 PM.

Course Description:
Pharmaceuticals have traditionally been administered to patients via oral routes that rely on ingestion of tablets, appropriate degradation absorption in the gastrointestinal tract and transport to target tissues. Many drugs are chemically unstable and are significantly degraded during the digestion and absorption processes. Furthermore, once in the circulatory system, these drugs do not necessarily reach their intended physiological sites and are distributed throughout the entire body. Advances in the formulations of chemical and protein-based therapeutic molecules and site-specific delivery systems have allowed for the development of targeted drug and protein therapies. The immergence of advanced delivery technologies for drugs and most recently genes, for gene therapy, has catapulted site-specific drug, protein and gene therapies into the forefront of pharmaceutical and biopharmaceutical research, process development and manufacturing.

Drug and Gene Delivery will address the historical perspectives and the science and technologies that form the basis of drug, protein and gene delivery systems. Presentations and interpretations of these advances in the lay press will also be reviewed and discussed. The therapeutic systems will be presented in the context of specific organ systems and associated pathophysiologies. Topics for discussion will include drug and gene therapies for cardiovascular disease, hormone therapies, bone and cartilage related therapies and genetically-based vaccines. The immerging areas of in utero and embryonic gene therapies will also be discussed.

Core Curriculum Requirement: No

Syllabus


Fall 2011

Environmental Health and Disease, (BIOL 1820) 

Instructor: Professor Michelle Embree Ku
Course Location: Pfizer, Inc. (Groton, CT Main Campus).
Time: Tuesdays, 3:30 - 6:30 PM.

Course Description:
Humans have a long history of trying to understand and control how the environment affects their physiology. From the ancient Romans’ appreciation of sewers and aqueducts to current interest in nanoparticles’ influence on human health, there has been the desire to manage our environment to better our health. Today, the issues surrounding environmental health are complex and understanding them involves a multidisciplinary approach, using principles from toxicology, pathology, epidemiology and risk assessment, to name a few. Additionally, ethical, legal, and social issues must be considered. Environmental Health and Disease (BIOL 1820) will introduce students to the fundamental science that helps to guide public policy and individual decisions about human exposure to environmental insults, whether the insult is natural or manufactured.

Topics covered will include:
Environmental Toxicology: how the body reacts to environmental insults
Environmental Epidemiology
Sources of exposure: physical, chemical, and biological agents
Risk management, ethical considerations and policy making
Risk communication and the media
Emerging issues in Environmental Health and Disease

Core Curriculum Requirement: No

Syllabus


Summer 2011

The Immune System, (BIOL 2640C) 

Instructor: Professor Richard Bungiro
Course Location: Pfizer, Inc. (Groton, CT Main Campus).
Time:  Tuesdays and Thursdays, 3:30 - 6:45 PM.

Course Goals:
Introduction to the experimental and theoretical foundations of immunology and the function of the mammalian immune system. Focuses on concepts, landmark experiments and recent advances. Topics include innate and adaptive immunity; structure/function of antibody molecules and T cell receptors; and regulation of immune responses through cellular interactions. Application of concepts to medically significant issues (vaccines, transplantation, hypersensitivity, autoimmunity, cancer, immunodeficiency) is discussed. Interpretative analysis of experimental data is emphasized. Activities include written assignments that analyze a hypothetical immune system and a final paper addressing an immunological topic of the student's choosing.

Core Curriculum Requirement: No

Syllabus


Spring 2011

Molecular Genetics, (BIOL 2540)

Instructor: Professor Mark Johnson
Course Location: Pfizer, Inc. (Groton, CT Main Campus).
Time: Wednesdays, 3:30-6:30 PM.

Course Goals:
‘Molecular Genetics’ represents a set of techniques used by biologists to understand how cells and organisms work. Students will read and discuss examples of how this set of tools has been applied to make fundamental contributions to our understanding of biological function.

Core Curriculum Requirement: Yes

Syllabus