Brown University's Biomedical Engineering Graduate Program has extensive participation from research groups across Brown and the surrounding hospitals. Each year, we feature a subset of these labs that have exciting, new research projects in need of talented doctoral students. We encourage interested applicants to browse this information along with the more complete list of faculty/labs to find the best fit(s).
Research areas: Structural biology, molecular simulation, neurodegeneration
The laboratory studies the structure, dynamics, and molecular interactions of protein aggregates to learn why these assemblies cause incurable neurodegenerative disease and to develop new therapeutic strategies. Using a combination of NMR spectroscopy, molecular simulation, and computer modeling supplemented by biophysical and imaging methods, we determine high-resolution structures of these species and their interactions with other macromolecules and membranes. Current projects in the group focus on RNA binding protein function and aggregation in Alzheimer’s Disease, Lou Gehrig’s disease and frontotemporal dementia, as well as collaborative work with Brown faculty using cell and animal models of disease. More information on Dr. Nicolas Fawzi and the Fawzi Lab can be found on their respective websites.
Research areas: Structural biology, NMR, X-ray, SAXS, Phosphatases & kinases
The research program in the Peti Laboratory is unified by a common theme: using structural biology, biochemistry and biophysics to transform our understanding of the molecular basis of cellular communication mediated by protein:protein interactions in eukaryotic and prokaryotic organisms. The rational is obvious: protein:protein interactions are the central biological language by which information is communicated throughout the body. When these interactions are disrupted, i.e. through genetic mutation or exposure to toxins, the result is disease and frequently death. In order to understand how distinct, tightly-regulated protein:protein complexes control processes as diverse as learning and bacterial biofilm formation, we must understand how proteins interact at an atomic level. To achieve this long-term goal, I have initiated numerous distinct projects, with the ultimate aim of developing efficient chemical interventions, e.g. drug design. During the last years we have made significant progress and thus are now optimally positioned to develop new cancer and immunosuppressant drugs. Website