Brown University School of Engineering

The Human Gut Microbiome in Health and Ulcerative Colitis

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Tuesday, May 08, 2012 12:00pm - 1:00pm

The Human Gut Microbiome in Health and Ulcerative Colitis Presented by Dr. Susan Huse Josephine Bay Paul Center Marine Biological Laboratory Woods Hole, MA Ulcerative colitis (UC) is an inflammatory bowel disease affecting up to 2% of the population in developed countries. Symptoms which include severe bleeding, diarrhea, and cancer are associated with dysbiosis – a shift in the colonic microbiome toward an unhealthy community. Many patients require the complete removal of their bowel and the creation of a small ileal pouch to mimic the colon function. Some patients develop a stable pouch microbiota and experience relief of their symptoms, while others suffer from recurring inflammation, pouchitis, caused again by dysbiosis. We are first assessing what defines a healthy colonic microbiome, and then using a longitudinal approach with UC patients who undergo the colectomy to evaluate the evolution of the microbiome in the newly created pouch, and how the pouch microbiome differs from the healthy state in patients suffering from recurring pouchitis. Tuesday, May 8, 2012 ~ 12:00 - 1:00 PM LABORATORIES FOR MOLECULAR MEDICINE (LMM) BUILDING 70 Ship Street, Auditorium (107) Providence, RI