Brown University School of Engineering

Center for Biomedical Engineering Seminar Designer Materials by Self- and Directed Assembly: Photorheological Fluids, Magnetic Microchains and Hemostatic Dressings

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Wednesday, April 17, 2013 11:00am - 12:00pm

Center for Biomedical Engineering Seminar Designer Materials by Self- and Directed Assembly: Photorheological Fluids, Magnetic Microchains and Hemostatic Dressings Srinivasa R. Raghavan Patrick & Marguerite Sung Professor Department of Chemical & Biomolecular Engineering University of Maryland, College Park, MD 20742 http://complexfluids.umd.edu Our laboratory seeks to engineer the assembly of ???building blocks??? such as polymers, surfactants, or colloids into higher-order materials. Such assembly can be induced spontaneously, guided by thermodynamic forces ??? this is called self-assembly. Alternately, assembly can be directed in specific ways, e.g., by bringing materials into contact at interfaces or around predefined templates ??? this can be termed directed assembly. Both processes have their analogs in biology and nature, and both are of great technological interest. This talk will provide illustrative examples of our work with self- and directed assembly. We have created assemblies that respond to stimuli such as temperature, pH or light; an example of the latter are photorheological fluids. Also, we have used microfluidic techniques to create magnetic microcapsules of biopolymers, which we have then linked into flexible microchains. We have also developed self-assembling biopolymers that have the ability to gel blood cells and thereby serve as effective hemostatic dressings for both military and civilian use. References: 1. A. M. Ketner, S. R. Raghavan, et al. J. Am. Chem. Soc., 129, 1553 (2007) 2. H. Y. Lee, S. R. Raghavan, et al. J. Am. Chem. Soc., 133, 8461 (2011) 3. K. Q. Jiang, D. L. DeVoe, S. R. Raghavan, et al. Small, 7, 2470 (2011) 4. J. H. Lee, G. F. Payne, S. R. Raghavan, et al. Langmuir 21, 26 (2005) 5. M. B. Dowling, S. R. Raghavan, et al. Biomaterials, 32, 3351 (2011) Date: Wednesday, April 17th Time: 11:00 AM - Noon Place: B&H 190