Faculty Profile: Jennifer Friedman, MD, PhD

Jennifer Friedman
Jennifer Friedman, MD, PhD
Associate Professor of Pediatrics
Pediatrics
Work: +1 401-444-7449
Dr. Friedman's research addresses how parasitic diseases, particularly malaria and schistosomiasis (a worm infection of the liver and intestines) cause morbidity for pregnant women and children. Previous research has addressed whether or not these infections are associated with adverse maternal and birth outcomes, malnutrition, anemia, and cognitive impairment. It has also examined how these parasites cause these problems to more effectively address best options for treating these morbidities.

Biography

Dr. Friedman is a pediatrician who conducts international health research out of Lifespan's Center for International Health Research. Her research addresses quantification of and mechanisms of morbidity of parasitic diseases among pregnant women and children.

Institutions

RIH

Research Description

Dr. Friedman's research addresses how parasitic diseases, particularly malaria and schistosomiasis cause morbidity for pregnant women and children. We have focused on how schistosomiasis causes anemia and undernutrition. In particular, we have identified anemia of inflammation as a primary cause of schistosomiasis related anemia. In addition, our studies suggest that pro-inflammatory cytokines may mediate under-nutrition in the context of S. japonicum, due to their cachexia and anorexia inducing effects.

Our current studies seek to quantify the burden of S. japonicum infection during pregnancy and begin to understand the possible mechanisms. The mechanisms that will be studied include placental inflammation, maternal anemia of inflammation, and maternal cachexia/anorexia. These will be addressed using a randomized controlled trial design that will begin subject recruitment in early 2007 in The Philippines.

Grants and Awards

Graduated Magna cum Laude, Brown University, 1992

Received Pediatric Clinical Honors in Pediatric Sub-Internship, 1995-1996
Pediatric Infectious Diseases, Adolescent Medicine, and Pediatric HIV Longitudinal

Fulbright fellowship to Kenya with Centers for Disease Control, 1996-1997

Honor Award for contribution to Insecticide Treated Bednet Trial, 2002
National Center for Infectious Diseases, Atlanta, GA

Partners in Public Health, Group Honor Award to Insecticide Treated Bednet Trial's Kenya Staff, 2002
National Center for Infectious Diseases, Atlanta, GA

Award for excellence in Teaching and Mentoring from Pediatric Residents, 2002
Hasbro Children's Hospital, Providence, RI

Fleet Community Fellow Award for Community Service, 2003
$10,000 Loan Repayment Award
Fleet Bank, Boston, MA

Charles C. Shepard Science Award Nomination, 2004
Presented to Authors of most outstanding peer-reviewed research papers published by
Centers for Disease Control and Agency for Toxic Substances and Disease Registry

Dean's Teaching Excellence Award, 2004
For exemplary teaching of medical students

Lifespan's Bruce Seyla Award for Research, 2012

Affiliations

Member, American Academy of Pediatrics, 1997-

Fellow, American Academy of Pediatrics, 2000-

Member, American Society of Tropical Medicine and Hygiene, 2001-

Member, Ambulatory Pediatric Association, 2000-

Funded Research

PAST:

Albert Einstein Young Scientist Research Fellowship, Summer 1991
Laboratory based research investigating B cell somatic hypermutation

National Institutes of Health Medical Student Summer Research Grant, Summer 1993
Laboratory based research investigating malaria parasite invasion of hepatocytes

Brown University Foreign Studies Fellowship to Brazil, 1995
Validation of a water contact questionnaire in an S. mansoni endemic village

US Fulbright Fellowship to Kenya, 1996-1997
Impact of insecticide treated bednets (ITBNs) on the growth, nutritional
status, and body composition of primary school children (Principal Investigator)
RCT of impact of ITBNs on under 5 morbidity and mortality (co-investigator)

Children's Hospital of Philadelphia Resident Research Grant, 1999
Travel funds to return to Kenya to oversee completion of ITBN project (above) (Principal Investigator)

CURRENT:

National Institutes of Allergy and Infectious Diseases, 8/2002-4/2007
K23AI52125-01
Mentored Patient Oriented Research Scientist Development Award
$115,525 annual direct costs
$9,242 annual indirect costs
"Mechanisms of S. Japonicum Associated Anemia and Malnutrition" (Principal Investigator)

National Institutes of Allergy and Infectious Diseases, 09/2005-8/2007
RO3AI64735
Small Grants (RO3)
$50,000 annual direct costs
$23,591 annual indirect costs
"Inflammation, Iron, and Cognition in S. japonicum" (Principal Investigator)

National Institutes of Allergy and Infectious Diseases, 04/2006-03/2011
RO-1AI066050
RO1 Investigator Initiated
$454,721 annual direct costs
$165,647 annual indirect costs
"S. Japonicum and pregnancy outcomes: an RCT" (Principal Investigator)

National Institutes of Allergy and Infectious Diseases, 10/2003-9/2006
Pediatric Research Loan Repayment Award
Annual Repayment of $28,640

Selected Publications

  • Coutinho, HM, Acosta, LP, McGarvey, ST, Jarilla, B, Jiz, M, Pablo, AO, Su, L, Manalo, DL, Olveda, RM Kurtis, JD, Friedman, JF. (2006) Nutritional status improves after treatment of Schistosoma japonicum infected children and adolescents. Journal of Nutrition, Vol 136(1), p. 183-8. (2006)
  • Leenstra, T, Acosta, LP, Langdon, GC, Manalo, DL, Su, L, Olveda, RM, McGarvey, ST, Kurtis, JD, Friedman, JF. (2006) Schistosomiasis japonica, anemia and iron status in children, adolescents and young adults in Leyte, the Philippines. Am J Clin Nutr, Vol 83(2), p. 371-9. (2006)
  • Ezeamama, A, Friedman, JF, Olveda, RM, Acosta, LP, Kurtis, JD, Mor, V, McGarvey, ST (2005) Functional Significance of Low Intensity Polyparasitism in Anemia. J Infect Dis, Vol 192(12), p. 2160-70. (2005)
  • Nixon, CP, Friedman, JF, Treanor, K, Knopf, PM, Duffy, PE, Kurtis, JD. (2005) Antibodies to Rhoptry-Associated Membrane Antigen Predict Resistance to Plasmodium falciparum. J Infect Dis,Vol 192(5), p. 861-9. (2005)
  • Coutinho, HM, McGarvey, ST, Acosta, LP, Manalo, DL, Langdon, GC, Leenstra, T, Kanzaria, HK, Solomon, J, Wu, H, Olveda, RM, Kurtis, JD, Friedman, JF. (2005) Nutritional status and serum cytokine profiles in children, adolescents and young adults with S. japonicum-associated hepatic fibrosis in Leyte, the Philippines. J Infect Dis, Vol 192(3), p. 528-36 (2005)
  • Friedman, JF, Kanzaria, HK, McGarvey, ST. (2005) Human schistosomiasis and anemia: the relationship and potential mechanisms. Trends in Parasitology,Vol 21(8), p.386-92. (2005)
  • Friedman, JF*, Ezeamama, A*, Acosta, LP, Langdon, GC, Bellinger, D, Manalo, DL, Olveda, RM, Kurtis, JD, McGarvey, ST (2005) Helminth infection and cognitive impairment among Filipino children. Am J Trop Med Hyg, Vol 72(5), p540-548. *joint first authorship (2005)
  • Kanzaria, HK, Acosta, LP, Langdon, GC, Manalo, DL, Olveda, RM, McGarvey, ST, Kurtis, JD, Friedman, JF. (2005) Schistosoma japonicum and occult blood loss in endemic villages in Leyte, The Philippines. Am J Trop Med Hyg,Vol 72(2), p 115-118. (2005)
  • Lee, G, Solomon, JA, Friedman, JF, Hibberd, PL, Ross-Degnan, D, Zasloff, E, Bediako, S, Goldmann, DA (2005) Factors Associated with Reduced Transmission of Daycare-Associated Illnesses in the Home: A possible role for alcohol-based hand gels. Pediatrics. Vol 115 (4), p 852-860. (2005)
  • Friedman, JF*, Kanzaria, HK*, Acosta, LP, Langdon, GC, Manalo, DL, Wu, H, Olveda, RM, McGarvey, ST, Kurtis, JD. (2005) Relationship between Schistosomiasis japonicum and nutritional status among children and young adults in Leyte, The Philippines. Am J Trop Med Hyg. Vol 72(5), p 527-533. *joint first authorship (2005)
  • Friedman, JF, Lee, G, Kleinman, K, Finkelstein, J. (2004) Child Care Center Policies and Practices for Management of Ill Children. Ambulatory Pediatrics. Vol 4(5), p 455-60 (2004)
  • Friedman, JF, Kurtis, JD, Mtalib, R, Opollo, M, Lanar, DE, Duffy, PE. (2003) Malaria is related to decreased nutritional status among adolescents and adults in the setting of intense perennial transmission. J Infect Dis, Vol 188(3), p449-57. (2003)
  • Ter Kuile, FO, Terlouw, DJ, Phillips-Howard, PA, Hawley, WA, Friedman, JF, Kariuki, SK, Shi, YP, Kolczak, MS, Lal, AA, Vulule, JM, Nahlen, BL. (2003) Permethrin-treated bednets reduce malaria in pregnancy in an area of intense perennial malaria transmission in western Kenya. Am J Trop Med Hyg. Vol 68(4S), p 50-60. (2003)
  • Ter Kuile, FO, Terlouw, DJ, Kariuki, SK, Phillips-Howard, PA, Mirel, LB, Hawley, WA, Friedman, JF, Shi,, YP, Kolczak, MS, Lal, AA, Vulule, J, Nahlen, BL.(2003) Impact of permethrin-treated bednets on malaria, anemia and growth in infants in an area of intense perennial malaria transmission in western Kenya. Am J Trop Med Hyg. Vol 68(4S), p