Faculty Profile: Amy Salisbury, PhD, MS, RN

Amy Salisbury
Amy Salisbury, PhD, MS, RN
Associate Professor of Pedicatrics (Research)
Bio Med Pediatrics
My research examines bio-behavioral development from before birth through early childhood. My research focuses on pathways of risk or resilience for psychopathology in children (autism, depression, sleep), effects of prenatal exposures, infant mental health, preterm infant development, and sleep development.

Biography

I was originally trained as a nurse and hold board-certification as a clinical nurse specialist in child and family psychiatry. I obtained my BA in Neuroscience from Clark University and earned my doctorate at the University of Connecticut in Biobehavioral Sciences/Developmental Psychobiology. I completed my postdoctoral research fellowship in the Department of Psychiatry and Human Behavior at Brown Medical School. My current research and clinical interests include neurobehavioral development, fetal and infant development, sleep development and disorders, perinatal and infant mental health, prenatal exposures, autism, and child psychopathology. I am currently conducting research on fetal and infant neurobehavioral development in relation to maternal depression and antidepressant treatment during pregnancy.

Research Description

The long term goal of my research program is examine potential mechanisms for the development of psychopathology in children in order to prevent such disorders, find better diagnostic tools and create better treatment options. My work includes consideration of variables that contribute to resilience in those children that do not develop a psychiatric diagnosis. This approach requires measurement of multiple systems of the developing child, including parental psychopathology and behavior, the infant-parent system, physiology, genetics, behavior, social communication, and the environment. The scope of my research program fosters collaboration with many other investigators at Brown University and other institutions.
My current research focuses on prenatal and postnatal neurobehavioral development of the fetus and fetal-maternal system in women who are depressed or using antidepressant medication. The goal of the study is to evaluate fetal neurobehavior during exposure to maternal Major Depressive Disorder (MDD) or SSRI medication use. Other applications of these data include examining the effect of SSRI medications on developing serotonin systems and how this may alter long-term behavioral and emotional outcomes.
Measurement of fetal neurobehavior is accomplished by monitoring and recording fetal heart rate, motor activity, behavioral state, and responsiveness to extra-uterine stimuli using a protocol and coding system we developed called the Fetal Neurobehavior Coding System (FENS). The FENS was patterned after the NICU Network Neurobehavioral Scale (NNNS) developed by Dr. Barry Lester for at-risk infants. The two methods are used across development for a cohesive assessment of neurobehavioral development.
We are currently using the FENS to study the effects of fetal exposure to antidepressant medications, maternal depression, and maternal smoking, as well as buprenorphine and methadone treatment of heroine addiction.

Grants and Awards

2003 NASPOG Young Investigator Award. The North American Society For Psychosocial Obstetrics and Gynecology for the paper entitled: "Fetal behavioral reactivity and depressed maternal mood".

2001 First Place Research Award for Post-Doctoral Fellows
Brown Medical School Department of Psychiatry and Human Behavior, 2001
Salisbury, A., Bocanegra, M., LaGasse, L., Lester, B. Ultrasound Evaluation of Fetal Behavior In Mothers with Depressed Mood.

Affiliations

International Society for Developmental Psychobiology
International Society for Infant Studies
Marcé Society
North American Society For Psychosocial Obstetrics and Gynecology (NASPOG)
Sleep Research Society
Society for Research in Child Development

Funded Research

CURRENT FUNDING:

2/1/2013-1/31/2018 R01 MH078033-06 Salisbury PI
Fetal and Neonatal Neurobehavior and Prenatal Antidepressant Exposure: The Child
NIMH Total Direct Costs $2,575,135 Indirect Costs $1,210,313

2/15/2012-1/31/2014 R03 MH096036-01 Principal Investigator
Sleep and biological rhythms after fetal exposure to antidepressants
NIMH Total Direct Costs $100,000 Indirect costs $45,500

9/1/2011-8/31/2016 R01DA031188-01 (PI: Stroud, L.) Co-Investigator
Maternal Smoking: HPA and Epigenetic Pathways to Infant Neurobehavioral Deficits
NIDA Total Direct Costs $2,345,350 Indirect Costs $1,009,440
Total Subcontract Direct Costs $354,545

8/1/2013 – 4/30/2018 R01DA036999-01 (PI: Stroud, L.) Co-Investigator
Fetal behavior, brain, & stress response: Ultrasound markers of maternal smoking
NIDA Total Direct Costs $2,020,041 Indirect Costs $655,598
Total Subcontract Direct Costs $460,207

Teaching Experience

I am available for independent study courses in developmental research.

Selected Publications

  • Lester BM, Miller RJ, Hawes K, et al. Infant neurobehavioral development. Seminars in perinatology. Feb 2011;35(1):8-19. (2011)
  • Coyle MG, Salisbury AL, Lester BM, et al. Neonatal Neurobehavior Effects following Buprenorphine versus Methadone Exposure. Addiction. 2011;in press. (2011)
  • Salisbury AL, Coyle MG, O'Grady KE, et al. Fetal Assessment before and after dosing with Buprenorphine or Methadone. Addiction. 2011;in press. (2011)
  • Salisbury, A.L., High, P., Twomey, J., Dickstein, S., Chapman, H. and Lester, B.M., A Randomized Control Trial to Evaluate a Family Based Biopsychosocial Intervention for the Treatment of Infant Colic, Infant Mental Health Journal, 2011 In press (2011)
  • Grant-Buettler M, Glynn LM, Salisbury AL, Davis EP, Sandman CA. Development of Fetal Movement between 26 and 36 Weeks' Gestation in Response to Vibro-acoustic Stimulation. Frontiers in Developmental Psychology. 2011;in press. (2011)
  • McFarland J, Salisbury AL, Battle CL, Hawes K, Halloran K, Lester BM. Major depressive disorder during pregnancy and emotional attachment to the fetus. Archives of Women's Mental Health. Oct 2011;14(5):425-434. (2011)
  • Ponder KL, Salisbury A, McGonnigal B, Laliberte A, Lester B, Padbury JF. Maternal depression and anxiety are associated with altered gene expression in the human placenta without modification by antidepressant use: Implications for fetal programming. Developmental Psychobiology. Nov 2011;53(7):711-723. (2011)
  • Salisbury AL, Wisner KL, Pearlstein T, Battle CL, Stroud L, Lester BM. Newborn neurobehavioral patterns are differentially related to prenatal maternal major depressive disorder and serotonin reuptake inhibitor treatment. Depression and Anxiety. Sep 2 2011. (2011)
  • Matook SA, Sullivan MC, Salisbury A, Miller RJ, Lester BM. Variations of NICU sound by location and time of day. Neonatal network : NN. Mar-Apr 1 2010;29(2):87-95. (2010)
  • Salisbury AL. Before Infant Assessment: Fetal neurobehavior. In: Lester BM, Sparrow JD, eds. Nurturing Children and Families: Building on the Legacy of T. Berry Brazelton West Sussex, UK: John Wiley and Sons; 2010:29-39. (2010)
  • Pearlstein T, Howard M, Salisbury A, Zlotnick C. Postpartum depression. American Journal of Obstetrics and Gynecology, 2009(4): 357-64. PMID:19318144 (2009)
  • Salisbury AL, Ponder KL, Padbury JF, Lester BM. Fetal effects of psychoactive drugs. Clin Perinatol. Sep 2009;36(3):595-619. (2009)
  • Stroud LR, Paster RL, Papandonatos GD, et al. Maternal smoking during pregnancy and newborn neurobehavior: effects at 10 to 27 days. The Journal of Pediatrics. Jan 2009;154(1):10-16. (2009)
  • Battle CL, Zlotnick C, Pearlstein T, et al. Depression and breastfeeding: which postpartum patients take antidepressant medications? Depress Anxiety. 2008;25(10):888-891. (2008)
  • Salisbury AL, Lester BM, Seifer R, et al. Prenatal cocaine use and maternal depression: effects on infant neurobehavior. Neurotoxicology and Teratology. May-Jun 2007;29(3):331-340. (2007)
  • Salisbury AL, Fallone MD, Lester B. Neurobehavioral assessment from fetus to infant: the NICU Network Neurobehavioral Scale and the Fetal Neurobehavior Coding Scale. Mental Retardation and Developmental Disabilities Research Reviews. 2005;11(1):14-20. (2005)
  • Salisbury AL, Yanni P, Lagasse LL, Lester B, eds. Maternal-Fetal Psychobiology: A Very Early Look at Emotional Development. Oxford, UK: Oxford University Press; 2004. Nadel J, Muir DW, eds. Emotional Development: Recent Research Advances. (2004)
  • Salisbury A, Law K, LaGasse L, Lester B. MSJAMA. Maternal-fetal attachment. Jama. Apr 2 2003;289(13):1701. (2003)
  • Salisbury AL, Minard K, Hunsley M, Thoman E. Audio Recording of Infant Crying: Comparison with Maternal Cry Logs. International Journal of Behavioral Development. 2001;25(5):458-465. (2001)