Faculty Profile: Ian Michelow, MD, FCPaed(SA), MMed, DTM&H

Ian Michelow, MD, FCPaed(SA), MMed, DTM&H
Assistant Professor of Pediatrics
Department of Pediatrics
Work: +1 401-444-6548
Dr. Michelow and his team use an innovative strategy to identify lead malaria vaccine candidates by screening virtually the entire falciparum malaria proteome. They use plasma from individuals with mild or severe malaria to interrogate malarial antigens expressed on bacteriophage display libraries. His goal is to rationally identify immunoprotective malaria antigens that can be used as vaccines for women in order to protect their offspring. Their research techniques include immunoepidemiologic modeling, differential affinity selection of peptides, protein expression and purification, antibody production, growth inhibition assays using live malaria parasites, high-resolution imaging and pre-clinical challenge models.

Biography

Dr. Michelow's experience and interests span clinical, laboratory-based and translational research topics. He has conducted studies in clinical epidemiology and biomarkers of pneumonia and viral infections in hospitalized neonates and children, innovative diagnostic assays for infants with congenital syphilis, and PK/PD parameters of novel antimicrobials in pre-clinical meningitis models. His research at the interface between infectious diseases and immunology led to the development of novel recombinant chimeric lectins for use as immunotherapeutics against emerging infectious diseases such as Ebola virus, and new insights into lectin-dependent enhancement of glycosylated virus infections which may explain the evolutionary selection of mutations in certain innate immune molecules.
Dr. Michelow currently collaborates with Drs. Jonathan Kurtis and Jennifer Friedman in the Center for International Health Research at Rhode Island Hospital and Brown University. His research currently focuses on early-stage development of falciparum malaria vaccines for pregnant women and their offspring.
Dr. Michelow is supported by the Rhode Island Foundation, Women & Infants Hospital, Lifespan Inc., the Department of Pediatrics at Hasbro Children's Hospital, and NIH/NIAID K08 and NIH/NIGMS COBRE grants.

Grants and Awards

Duncan Prize
London School of Hygiene and Tropical Medicine, United Kingdom, 1998

Dean's Excellence in Teaching Award
Alpert Medical School of Brown University, Providence, RI, 2012

Exemplary Teaching Award
Alpert Medical School of Brown University, Providence, RI, 2013

Affiliations

American Society of Microbiology
American Society of Tropical Medicine and Hygiene
Infectious Diseases Society of America
Pediatric Infectious Disease Society
Society for Pediatric Research

Funded Research

Rhode Island Foundation
Lifespan Inc.
Women & Infants Hospital
Brown University
NIH/NIAID K08
NIH/NIGMS COBRE

Teaching Experience

Pediatric Infectious Diseases
Parasitology
Clinical Immunology

Courses Taught

  • IMS-II: Microbiology/Infectious Diseases Course (BIOL 3653)

Selected Publications

  • Michelow IC. American Academy of Pediatrics. Hemorrhagic fevers and related syndromes caused by viruses of the family Bunyaviridae. In: Kimberlin DW, ed. Red Book: 2015 Report of the Committee on Infectious Diseases. 30th ed. Elk Grove Village, IL: American Academy of Pediatrics; 2015 [in press] (2015)
  • Dennehy PD, Michelow IC, Alexander N, Koster M. Active immunizing agents. In: Feigin, Cherry, Demmler-Harrison, and Kaplan: Textbook of Pediatric Infectious Diseases, 7th ed. Philadelphia, Saunders; 2015 [in press] (2015)
  • Michelow IC. American Academy of Pediatrics. Hemorrhagic fevers caused by arenaviruses. In: Kimberlin DW, ed. Red Book: 2015 Report of the Committee on Infectious Diseases. 30th ed. Elk Grove Village, IL: American Academy of Pediatrics; 2015 [in press] (2015)
  • Matthew Brudner, Marshall Karpel, Calli Lear, Li Chen, L. Michael Yantosca, Corinne Scully, Ashish Sarraju, Anna Sokolovska, M. Reza Zariffard, Damon P. Eisen, Bruce A. Mungall, Darrell N. Kotton, Amel Omari, I-Chueh Huang, Michael Farzan, Kazue Takahashi, Lynda Stuart, Gregory L. Stahl, Alan B. Ezekowitz, Gregory T. Spear, Gene G. Olinger, Emmett V. Schmidt, Ian C. Michelow. Lectin-dependent enhancement of Ebola virus infection via soluble and transmembrane C-type lectin receptors. PLoS ONE 2013; 8(4): e60838. doi:10.1371/journal.pone. 0060838 (2013)
  • Chia-Hua Chiu*, Ian C. Michelow*, Valerie Buckley, Jonathan Cronin, Timothy G. Ferris, Steven A. Ringer, Karen M. Puopolo. Effectiveness of a Guideline to Reduce Vancomycin Administration in the Neonatal Intensive Care Unit. Pediatr Infect Dis J 2011;30:273-8 (* these authors contributed equally) (2011)
  • Ian C. Michelow, Callie Lear, Xin Ji, Mathew Brudner, Marshall Karpel, Kazue Takahashi, Gregory T. Spear, Alan B. Ezekowitz, Emmett V. Schmidt, Gene G. Olinger. High-Dose Mannose-binding lectin therapy for Ebola virus infection.J Infect Dis 2011;203:175-9 (2011)
  • George Russell, Jess Kaplan, Maryjane Ferraro, Ian C. Michelow. Fecal bacteriotherapy for relapsing Clostridium difficile infection in a child: a proposed treatment protocol. Pediatrics 2010;126(1):e239-42 (2010)
  • Ian C. Michelow, Mingdong Dong, Bruce A. Mungall, L. Michael Yantosca, Callie Lear, Xin Ji, Marshall Karpel, Christina L. Rootes, Gunnar Houen, Damon P. Eisen, T. Bernard Kinane, Kazue Takahashi, Gregory L. Stahl, Gene G. Olinger, Gregory T. Spear, Alan B. Ezekowitz, Emmett V. Schmidt. A Novel L-Ficolin/Mannose Binding Lectin Chimeric Molecule with Enhanced Anti-viral Activity against Ebola Virus.J Biol Chem 2010;285:24729-39 (2010)
  • Michelow IC and McCracken GH, Jr. Antibacterial therapeutic agents. In : Feigin, Cherry, Demmler-Harrison, and Kaplan: Textbook of Pediatric Infectious Diseases, 6th ed. Philadelphia, Saunders. 2009: 3178-227 (2009)
  • Takahashi K, Ip EWK, Michelow IC, Ezekowitz, RAB. The mannose-binding lectin: a prototypic pattern recognition molecule. Curr Opin Immunol 2006;18:16-23 (2006)
  • Ian C. Michelow, Kurt Olsen, Juanita Lozano, Lynn B. Duffy, George H. McCracken, and R. Doug Hardy. Diagnostic Utility and Clinical Significance of Naso- and Oropharyngeal Samples Used in a PCR Assay to Diagnose Mycoplasma pneumoniae Infection in Children with Community-Acquired Pneumonia. J Clin Microbiol 2004;42:3339-41 (2004)
  • Ian C. Michelow, Kurt Olsen, Juanita Lozano, Nancy K. Rollins, Lynn B. Duffy, Thedi Ziegler, Jaana Kauppila, Maija Leinonen, George H. McCracken, Jr. Epidemiology and outcome of community-acquired pneumonia in hospitalized children. Pediatrics 2004;113:701-7 (2004)
  • Michelow IC, Wendel GD, Norgard M, Zeray F, Leos NK, Alsaadi R, and Sánchez PJ. Central nervous system invasion by Treponema pallidum in congenital syphilis. N Engl J Med 2002; 346:1792-8 (2002)
  • Michelow IC, Lozano J, Olsen K, Goto C, Rollins NK, Ghaffar F, Rodriguez-Cerrato V, Leinonen M, and McCracken GH Jr. Diagnosis of Streptococcus pneumoniae lower respiratory infection in hospitalized children by culture, polymerase chain reaction, serological testing, and urinary antigen detection. Clin Infect Dis 2002; 34: e1-11 (2002)