Faculty Profile: Gregory Jay, MD, PHD

Gregory Jay
Gregory Jay, MD, PHD
Professor of Emergency Medicine
Emergency Medicine
Work: +1 401-444-6238
Dr. Jay has investigated the lubricating properties of synovial fluid and what role it may play in degenerative joint diseases. He confirmed that lubricin is a mucinous glycoprotein and showed that the glycosylations on this molecule provide for a lower coefficient of friction between both biological and non-biological rubbing surfaces. He is interested in more immediate translational studies in the areas of automated pulsus paradoxus monitoring in emergency medicine. He has developed and/or tested a portable hyperbaric chamber system, bedside co-oximetry, and other novel devices.

Biography

GREGORY D. JAY, MD, PhD, is Professor of Emergency Medicine and Engineering at Brown University in the Department of Emergency Medicine and Division of Engineering, and an attending physician at Rhode Island Hospital. In October 2004 Dr. Jay was selected as recipient of the Bruce M. Selya Award for Research Excellence.

Institutions

Rih

Research Description

Dr. Gregory D. Jay, Associate Professor, received his M.D., Ph.D. from the Medical Scientist Training Program at the State University of New York at Stony Brook in 1990. He completed training in emergency medicine at the University of Massachusetts from 1990 through 1993 and became a fellow of the American College of Emergency Physicians in 1996. Dr. Jay also served in the Air National Guard during 1986 through 1998 serving as a flight surgeon in the 106th Aerospace Rescue & Recovery Group and the 143rd Tactical Airlift Group. Dr. Jay is an Associate Professor of Emergency Medicine, Medicine and Engineering, and is an Adjunct Professor in Biomedical Sciences at the University of Rhode Island. He has published over 50 peer-reviewed publications, and has 13 U.S. and international patents. Dr. Jay serves as Director of Research in the Department of Emergency Medicine at Brown University. He has been the principal investigator or co-investigator on multiple National Institutes of Health (NIH) and National Science Foundation (NSF) grants supporting his research on mammalian joint lubrication and how this system prevents degenerative joint disease. He has also developed and investigated the clinical utility of automated pulsus paradoxus monitoring in emergency medicine. Dr. Jay has also worked constructively with industry in helping develop portable hyperbaric systems, bedside co-oximetry, and other novel devices.

Grants and Awards

Fellowship/Scholarship: McCutchen Foundation Graduate Fellowship (1987-1988)

Society for Academic Emergency Medicine 1999 Annual Scientific Meeting: Best Basic Science Poster

Society for Academic Emergency Medicine 2000 Annual Scientific Meeting: Young Investigator Award

Hospital Association of Rhode Island Public Service Award 2001

Bruce Selya Young Investigator Award 2004

Affiliations

American Association for the Advancement of Science (1984-2005)

American College of Emergency Physicians (1993-2005)

Society for Academic Emergency Medicine (1993-2005)

Orthopaedic Research Society (2004-2005)

Aerospace Medical Association (1984-2005)

Association of Military Surgeons of the United States (1989-1994)

Undersea and Hyperbaric Medical Society (1994-2005)

American College of Forensic Examiners (1998-2004)

Society for Academic Emergency Medicine
New England Research Directors, Founding Member (1995-2005)
Chair, 1st New England Regional SAEM Scientific Meeting (1997)
Chair, 9th New England Regional SAEM Scientific Meeting (2005)

Society for Academic Emergency Medicine
Patient Safety Task Force (2000-2003)
Research Fellowship Grant Selection Committee (2001-2003)

American College of Emergency Physicians
Patient Safety in the ED Environment Task Force (2002-2003)

Annals of Biomedical Engineering (Reviewer) (1998-2005)

Obstetrics and Gynecology (Reviewer) (1998-2004)

Annals of Emergency Medicine (Reviewer) (1998-2005)

Arthritis and Rheumatism (Reviewer) (2002-2005)

Journal of Orthopaedic Research (Reviewer) (2002-2005)

Clinical Sciences Monitor (Reviewer) (2001-2005)

International Journal of Cell Biology (Reviewer) (2001-2004)

American Institute of Biological Sciences (Grant Reviewer) (1995-2004)

National Institutes of Health Bioengineering Study Section ZRG1 SSS-M01 & 02 (2001-2002)

National Institutes of Health Bioengineering Study Section ZRG1 SSS-M03 (2002)

National Institutes of Health Bioengineering Study Section ZRG1 SSS-M53 (2003-2004)

National Institutes of Health Bioengineering Study Section ZRG1 SBIB-G (2004)

State of Rhode Island Attorney General's Quality Institute (2002)

Spectra Research Inc. (Scientific Advisory Board) (2002)

Arthritis Research Campaign, United Kingdom (Reviewer) (2005)

Purdue Pharma (Expert consultant on synovial biomechanics) (1997-1998)

Bretton Industries (Expert consultant on portable hyperbaric oxygen systems) (1993-2001)

Dynamics Research Corporation (Expert consultant on application of crew resource management systems from aviation to medicine) (1994-1996)

Arthur D. Little (Expert consultant on synovial biomechanics) (1993-1994)

Voluntary Hospital Association of America (Patient safety systems) (2001-2002)

American Institutes for Research (AIR)/Agency for Healthcare Research and Quality (2003)

Anteon (Army SBIR Review Program: 72 hr Field Blood Storage Containers) (2003-2004)

University of Rhode Island: Adjunct Assistant Professor of Biomedical Sciences
(2001-2002)

Adjunct Associate Professor of Biomedical Sciences
(2003-2005)

United States Air Force/Air National Guard Medical Service Corp: Medical Student Early Commissioning (1986-1990)

Medical Corp: Flight Surgeon (1990-1997)

106th Aerospace Rescue and Recovery Group
Westhampton Beach, N.Y. (1986-1994)

143rd Tactical Airlift Wing, North Kingstown, R.I. (1995-1997)

Inactive Ready Reserve (1998-2005)

Funded Research

GRANTS

  1. "Isolation of Lubricin from Human Synovial Fibroblasts and Development of Immunological Probes". Principal Investigator; $19,630 awarded by Rhode Island Hospital; 12/1/1995-11/30/1996.

  2. "Medical Error Reduction: Emergency Medical Team Performance (MedTeams®) Phase I & II". Co-Principal Investigator; $855,533 awarded by Army Research Laboratory—Contract #DAAL01-96-C-0091, Aberdeen Proving Grounds subcontracted through Dynamics Research Corporation, Wilmington, MA; 9/1/1996-2/29/2000.

  3. "Medical Error Reduction: Emergency Medical Team Performance (MedTeams®) Phase III. Development of the Emergency Team Coordination Course Supported by High Fidelity Simulation Training to Improve Team Performance (ETCC-S)". Co-Principal Investigator; $154,152 awarded by Army Research Laboratory—Contract #DAAL01-96-C-0091, Aberdeen Proving Grounds subcontracted through Dynamics Research Corporation, Wilmington, MA; 3/1/2000-3/1/2001.

  4. "Immunoprobes for Human Lubricin from Human Synovial Fluid". Mentored Clinical Scientist Development Award; National Institutes of Health, National Institute on Aging, 1K08AG/AR01008-01; Principal Investigator; $386,553 awarded 8/1/2000-8/1/2004. Mentor: Douglas Hixson, Ph.D.

  5. "Study of Biological Boundary Lubrication using Atomic Force Microscopy in the Pulsed Force Mode". McCutchen Foundation; Principal Investigator; $34,700 awarded 1/1/2001-1/1/2002.

  6. "Design and Construction of a High Fidelity Medical Simulation Suite at Rhode Island Hospital". Champlin Foundation; Co-Principal Investigator; $100,000 awarded 12/1/2000-12/1/2001.

  7. "Developmental Center for Evaluation and Research in Patient Safety (DCERPS)". Agency for Healthcare Research and Quality, P20HF11592; Co-Investigator, Principal Investigator—Dr. Robert Wears, University of Florida, Co-Principal Investigator—Dr. Marc Shapiro, Brown University School of Medicine; $100,135 awarded 9/01/2001-8/31/2004.

  8. "Pneumothorax Detection System (PDS)". National Institutes of Health, National Heart, Lung and Blood Institute, R44 HL66126, Phase II—Small Business Innovation Research Award, Co-Investigator; Principal Investigator—Dr. Ronald G. Riechers, Spectra Research Inc.; $208,437 awarded 9/1/2002-8/31/2004.

  9. "Lubricin in Articulating Joints". National Institutes of Health, National Institute of Arthritis, Musculoskeletal and Skin Diseases, RO1 AR050180-01; Co-Investigator with Matthew Warman, M.D. at Case Western Reserve University; $2,159,560 awarded 7/1/2003-8/31/2008.

  10. "Acquisition of a Nanoindentation System for Multi-disciplinary Research and Education in Nano and Bio-mechanics of Materials". National Science Foundation, CMS-0421199; Co-Principal Investigator with P.R. Guduru, B.W. Sheldon, R.F. Cooper and K-S. Kim; $249,515 awarded 7/15/2004-6/30/2005.

  11. "Pulsus Paradoxus Monitor". National Institutes of Health, National Institute of Heart, Lung and Blood, R41 HL74633-01; Principal Investigator; Small Business Technology Transfer Award to Plethlogic Inc.; $298,776 awarded 9/1/2004-8/31/2006.

  12. "Non-invasive Device to Measure Hemoglobin Levels: Improving the Quality of Life of Persons with Life Altering Diseases". Culpeper Foundation; Co-Principal Investigator with G. Crawford; $25,000 awarded 10/1/2004-9/30/2006.

Selected Publications

  • Elsaid, KA, Jay, GD, Chichester, CO: Detection of collagen type II and proteoglycans in the synovial fluids of patients diagnosed with non-Infectious knee joint synovitis indicates early damage to the articular cartilage matrix. Osteoarthritis & Cartilage 11:673-680, 2003 (2003)
  • Morey, J, Simon, R, Jay, GD, Wears, RL, Salisbury, M, Berns, SD and the MedTeams Research Consortium: Error reduction and performance improvement in the Emergency Department through teamwork training: Validation results of the MedTeams Project. Health Services Research 37(6):1553-1581, 2002. (2002)
  • Jay, GD, Harris, DA, Cha, CJ: Boundary lubrication by lubricin is mediated by O-linked b(1-3)Gal-GalNAc oligosaccharides. Glycoconjugate Journal 18, 807-815, 2002. (2002)