Faculty Profile: Paul Malloy, PHD

Paul Malloy
Paul Malloy, PHD
Professor of Psychiatry & Human Behavior
Psychiatry & Human Behavior
Work: +1 401-455-6355
Paul Malloy's primary research interest is frontal lobe/executive functions in neuropsychiatric disorders, with a current focus on dementia. He is investigating the role of small vessel cerebrovascular disease in causing executive deficits using behavioral and neuroimaging techniques. In addition, a series of projects have demonstrated the relationship between executive problems and poor outcomes such as increased caregiver burden, failure in activities of daily living, and apathy. He is also involved in studies measuring executive functioning in obsessive-compulsive disorder (OCD) and depression in patients undergoing deep brain stimulation treatment.

Biography

Dr. Malloy graduated from Dartmouth College in 1972, and served as a Navy officer for the next four years. He earned a PhD in clinical psychology from SUNY Binghamton in 1981. He has been on the Brown Faculty since 1983. He serves as Director of Psychology and Co-Director of the Memory and Aging Program at Butler Hospital. He coordinated the Neuropsychology Track of the Brown Clinical Psychology Training Consortium for many years, and is now Associate Director of the Psychology Division of the DPHB.

Institutions

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Research Description

My research focuses on the functions of the frontal lobes of the brain in normal behavior and in disease. Toward that end, my colleagues and I have conducted research on a wide variety of populations, ranging from normal elderly to patients with brain lesions. Among the topics we have studied in recent years are:

- The relationship between executive problems and activities of daily living in the elderly;
- Measurement of non-cognitive behavior change in dementia;
- The role of frontal dysfunction in obsessive-compulsive disorder (OCD).

Methodological efforts have included the development of the Frontal Systems Behavior Scale (FrSBe) (designed to measure dysexecutive, disinhibited, and apathetic changes in behavior after brain injury) and analysis of MRI scans to measure small-vessel cerebrovascular disease.

Grants and Awards

1995 Outstanding Teaching Award in Psychology, Brown Medical School
1995 Fellow, National Academy of Neuropsychology
2002 Fellow, American Neuropsychiatric Association
2002 Dean's Teaching Excellence Award, Brown Medical School
2002 Dean's Teaching Excellence Award, Brown Medical School

Affiliations

1983- National Academy of Neuropsychology
1983- International Neuropsychological Society
1983- American Psychological Association (APA), Division 40 (Neuropsychology)
1993- American Neuropsychiatric Association, Research Committee
1993- American Neuropsychiatric Association, Chair, Website Committee
1993- American Neuropsychiatric Association, Advisory Committee
1999 American Neuropsychiatric Association, Annual Meeting program committee
1999 International Neuropsychological Society, Annual Meeting program committee
2000- International Neuropsychological Society, Continuing Education Committee
2000- National Academy of Neuropsychology, Professional Affairs Office
2002- Association for Internship Training in Clinical Neuropsychology Board Member
2006 - APA Division 40 Annual Meeting Program Committee

Funded Research

1983-1988 Co-investigator, Environmental treatment of alcohol abusers.
(National Institute on Alcohol Abuse and Alcoholism (NIAAA)-AA05827-01A. $677,258).

1983-1988 Co-investigator, Prediction of treatment outcome in alcoholism using neuropsychological tests.
(NIAAA-AA06698-01. $38,966).

1985 Co-investigator, Treatment of memory deficits in Korsakoff's patients with guanfacine.
(A. H. Robins Pharmaceuticals. $92,750).

1988-1989 Co-investigator, Environmental treatment of alcohol abusers, competitive renewal.
(NIAAA-AA06698-04. $137,756).

1989-1992 Co-investigator, Treatment of primary degenerative dementia with nimodopine.
(Miles Laboratories. $440,000).

1993-1995 Principal Investigator. Multicenter comparison of placebo and Mentane in outpatients with Alzheimer's disease.
(Hoechst Celenase Corp.)

1994-1995 Principal Investigator. Development of a computerized teaching program in neuroimaging.
(Wayland Collegium, Brown University... $2500).

1993-1995 Principal Investigator. Quantitative MRI analysis of subcortical white matter changes in late-life onset depression.
(Brown University Department of Psychiatry and Human Behavior. $46,000).

1997-1998 Co-investigator. An eight-week, parallel group, double-blind, placebo-controlled study of sertraline in elderly outpatients with major depression.
(Pfizer Pharmaceuticals R-0552).

1997-2001 Principal Investigator. Relationship of MRI hyperintensities to treatment response in geriatric depression.
(Pfizer Pharmaceuticals R-0552. $50,000).

1997-2002 Co-investigator. Attentional and cognitive training in vital community elderly (ACTIVE).
(National Institute on Aging (NIA) 5U101 NR4507-03).

1998-2001 Co-investigator. A multi-center evaluation of the efficacy and safety of donepezil hydrochloride in patients with dementia associated with cerebrovascular disease.
(Eisai Inc. E2020-A0001-307).

1998-2000 Principal Investigator. A multicenter evaluation of the efficacy and safety of donepezil hydrochloride (E2020) in subjects with mild cognitive impairment.
(Eisai/Pfizer E2020-A001-401).

1999-2004 Co- investigator; PI: R. Cohen. Heart disease, CNS dysfunction, and outcome in the elderly.
(National Institutes of Health (NIH)-NIA RO1 1999-PRG-1837)

2000-2001 Co-investigator; PI: D. Cahn-Weiner. Combined Pharmacologic and Behavioral Intervention to Improve Memory in Alzheimer's Disease
(Alzheimer's Association).

2000-2001 Co-investigator. Relationship of MRI hyperintensities to treatment response in geriatric depression.
(PI: R. Krishnan; Pfizer Pharmaceuticals R-0552).

2000-2002 Co-investigator; M. Aloia, PI. Improving sleep and cognitive functioning in Alzheimer's Disease.
(Pfizer Pharmaceuticals, investigator-initiated).

2000-2001 Co-Investigator. A randomized double blind placebo-controlled trial to evaluate the efficacy and safety of galantamine in subjects with mild cognitive impairment (MCI) clinically at risk for development of clinically probable Alzheimer's Disease.
(Jannsen Research Foundation GAL-INT-11).

2000-2004 Co-Principal Investigator, Butler site; PI: M. Sano. Alzheimer's disease prevention trial with estrogens.
(NIA)

2001-2003 Co-Principal Investigator; Co-PI: Patricia Boyle. Pharmacologic vs. combined pharmacologic-behavioral treatment for apathy in Alzheimer's disease.
(Alzheimer's Association, NIRG-01-2686).

2001-2002 Co-investigator. A double-blind, randomized pilot study to evaluate the effects of galantamine and donepezil on sleep and attention and GI tolerance in patients with mild to moderate Alzheimer's disease.
(Janssen Research Foundation, GAL-USA-24).

2002-2003 Co-Investigator. A 12-week, double-blind study in patients with mild to moderate Alzheimer's disease who either continue ongoing Donepezil therapy or switch to Galantamine Hydrobromide.
(Eisai Inc., E2020-A001-411).

2002-2003 Co-Investigator; PI-John Morris. Cognitive approach to maintaining self-care involvement.
(NIA 3 U01 NR04507-0582).

2003 Co-Principal Investigator. A randomized, double-blind, placebo-controlled study of C105 (levo-amphetamine sulfate) to improve memory in patients suffering from anterior communicating aneurysm syndrome.
(Sention, Inc. 22013. $22,552).

2003-2004 Co-Principal Investigator. A randomized, double-blind, placebo-controlled study of C105 to improve memory in patients suffering from mild cognitive impairment.
(Sention, Inc. 22020. $157,400).

2003 Co-Investigator. A Phase II Double-Blind, Randomized, Dose-Ranging, Placebo-Controlled, Multicenter, Safety and Efficacy Evaluation of Three Doses of NS 2330 in Patients with Mild to Moderate Dementia of the Alzheimer's Type.
(Boehringer Ingelheim Pharmaceuticals, Inc #1198.052. $51,020).

2003-2004 Co-Principal Investigator. A 24-week, multi-centered, randomized, double-blind, placebo-controlled evaluation of the efficacy, safety and tolerability of donepezil hydrochloride (E2020) in patients with dementia associated with cerebrovascular disease.
(Eisai Medical Research, Inc. # E2020-A001-319. $132,820)

2003-2004 Co-Principal Investigator. An 80-week, randomized, multi-center, parallel-group, double-blind study of the efficacy and safety of atorvastatin 80 mg plus an acetylcholinesterase inhibitor versus an acetylcholinesterase inhibitor alone in the treatment of mild to moderate Alzheimer's disease.
(Pfizer, Inc #A2581078. $274,240).

2003-2005 Co-Investigator; PI: S. Correia, Working memory and frontal white matter integrity in mild cognitive impairment.
(Alzheimer's Association.).

2003-2008 Principal Investigator. Brown Dementia Research Fellowship.
(NIA #T32 AG0200498-01A1. $1,135,000).

2004- Co-Investigator. A 1-year, multicenter, randomized, double-blind, placebo-controlled evaluation of the efficacy and safety of Donepezil Hyudrochloride (E2020) in subjects with mild cognitive impairment.
(Eisai # E2020-A001-412).

2004- Co-investigator. Galantamine ER open label rapid dose escalation trial in Alzheimer's disease.
(Janssen Pharmaceutica #GAL-ALZ-303. $32,000)

2004- Co-investigator. A double-blind, phase II, safety and efficacy evaluation of ONO-2506PO in patients with mild to moderate Alzheimer's disease.
(Ono Pharmaceutical Co. ONO-2506POU010. $214,890).

2004- Co-Investigator. A phase III study of the efficacy and safety of Alzhemed™ in patients in mild to moderate Alzheimer's disease
(Neurochem #CL-758007. $231,000).

2004- Co-Investigator. An open-label eight week investigation of the safety and efficacy of escitalopram for the treatment of anxiety and depression in dementia caregivers.
(Forest Laboratories).

2005- Co-investigator; PI: D. Laidlaw. Metrics for qualifying white matter: Image analysis, testing, and application.
(Brown intramural Office of Research award. $100,000).

2006- Principal Investigator. Treatment of apathy in Alzheimer's disease with Modafinil. Investigator initiated study.
(Cephalon Pharmaceuticals. $40,000).

Teaching Experience

2003-2008 Director, Brown Dementia Research Fellowship. A NIA-supported T32 program designed to train dementia researchers. The program involves faculty from four hospitals and six Brown departments.

2001-2010 Associate Director, Brown University Psychology Training Consortium. Responsible for supervision of the postdoctoral research training portion of the Consortium, which involves over 30 trainees per year in T32 and F32 supported positions.

1984 - 2001 Neuropsychology Track Coordinator. Coordinated and developed this track of the Brown University Psychology Consortium from its inception. Responsible for administration of training of all neuropsychology students, organization of seminars for the track, and establishment of community/research placements.

1984- Neuropsychology Rotation Supervisor. Supervise Butler Hospital rotation for a full-time intern in the neuropsychology track of the Psychology Internship Consortium.

1987- Neuropsychology Post-doctoral Fellowship Supervisor. Provide supervision for one to two full-time post-doctoral fellow in the neuropsychology track of the Psychology Training Consortium, conducting clinical and research activities at Butler.

1988- Brown Alcohol & Addictions Center Post-Doctoral Supervisor. Provided mentorship for four full-time post-doctoral fellows, conducting clinical and research activities in neuropsychological aspects of alcohol abuse.

1988- Brown Alcohol & Addictions Center Faculty Member.
Teach seminar sequence on neuropsychological impairment in alcohol for post-doctoral fellows of the Center. Act as resource for research activities of fellows.

1984- Brown Psychology Internship Core Seminar
Neuropsychology of alcohol abuse

1984- Neuropsychology Internship & Fellowship Seminar
Neuroimaging
Neuropsychiatric disorders
Frontal lobe disorders

1990- Psychiatry Resident PGY-3 Seminars
Neuropsychiatry: Introduction to functional neuroanatomy
Neuropsychiatry: Neuropsychological assessment
Neuropsychiatry: Frontal lobe syndromes
Neuropsychiatry: Sequelae of alcohol abuse
Forensics: Detecting malingering and exaggeration

1990- Psychiatry Resident PGY-4 Seminars
Introduction to neuropsychological testing

1998- Geriatric Psychiatry Fellowship Seminar
Age-associated memory impairment
Neuropsychological assessment in the elderly
Psychotic disorders in the elderly

1998- Biomed 370-The Human Brain and Behavior
Frontal lobe function and dysfunction

Selected Publications

  • Malloy, P.F., Correia, S., Stebbins, G., & Laidlaw, D. (2007). Neuroimaging of white matter in aging and dementia. The Clinical Neuropsychologist, 21, 1-38. (2007)
  • Malloy, P.F., Tremont, G., Grace, J., & Frakey, L. The Frontal Systems Behavior Scale (FrSBe) discriminates frontotemporal dementia from Alzheimer's disease. Alzheimer's and Related Disorders: Journal of the Alzheimer's Association. (2007)
  • Malloy, P.F. & Grace, J. (2005). A review of rating scales for measuring behavior change due to frontal systems damage. Cognitive and Behavioral Neurology, 18, 18-27. (2005)
  • Grace, J. & Malloy, P.F. (2002). The Frontal Systems Behavior Scale (FrSBe). Psychological Assessment Resources, Odessa, FL. (2002)
  • Salloway S, Malloy P, Duffy J. (2001). The frontal lobes and neuropsychiatric illness. American Psychiatric Press Inc., Washington, D.C. (2001)
  • Malloy, P.F., & Aloia, M. (1998). Frontal lobe dysfunction in traumatic brain injury. Seminars in Clinical Neuropsychiatry, 3, 186-194. (1998)
  • Malloy, P.F. & Duffy, J. (1994). The frontal lobes in neuropsychiatric disorder. In F. Boller & J. Grafman (Eds.), Handbook of Neuropsychology (Vol. 9), 203-232. (1994)
  • Malloy, P.F. & Richardson, E.D. (1994). The frontal lobes and content-specific delusions. Journal of Neuropsychiatry and Clinical Neuroscience, 6, 455-466. (1994)
  • Malloy, P. F., Rasmussen, S., Braden, W. and Haier, R. (1989). Topographic evoked potential mapping in obsessive-compulsive disorder: Evidence of frontal lobe dysfunction. Psychiatry Research, 28, 63-71. (1989)