Faculty Profile: Edith Mathiowitz, Ph,D., Weizman Institute of Science, Israel, 1985

Edith Mathiowitz
Edith Mathiowitz, Ph,D., Weizman Institute of Science, Israel, 1985
Professor
Molecular Pharmacology, Physiology & Biotechnology
Work: +1 401-863-1358
Research in our laboratory focuses on the polymer science-medicine interface. Areas of interest include development and modeling of novel drug delivery systems, particularly for the release of insulin and growth factors; designing small-diameter vascular grafts with better compliance; development of novel bioadhesive polymers for oral delivery systems; liquid crystals as smart sensors; the use of nanoparticles as novel therapeutic delivery systems (nanomedicine), tissue markings, DNA delivery.

Biography

Dr. Mathiowitz, Professor of Medical Science & Engineering and Director of the Biotechnology Graduate Program in the Department of Molecular Pharmacology and Biotechnology of Brown University, received her Ph.D. in the Department of Structural Chemistry at the Weizmann Institute. At MIT, she continued her research as a postdoctoral student under Dr. Robert Langer. Since then, Dr. Mathiowitz has been involved in research developing oral bioadhesive delivery systems for Proteins and genes, microencapsulation of proteins and genes, and tissue engineering of vascular grafts. She has published 90 papers, has 30 patents, and is a consultant to many biotech companies. She was the founder of Spherics, a previous RI Biotech company and a co-founder of Perosphere.

Institutions

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Research Description

Research in our laboratory focuses on the interface between polymer science and biology. Areas of interest include:


  • Tissue engineering and drug ad gene delivery;

  • Development, modeling, and morphological analysis of novel drug delivery systems, particularly for the release of macromolecules, such as insulin and growth factors;

  • Synthesis and characterization of biomaterials for drug delivery systems;

  • Studies of polymer-protein interactions with emphasis in the development of bioerodible polymers involving the use of mild fabrication techniques;

  • Developing of bioadhesive polymers for use as oral delivery systems;

  • Design and development of modulated sensors that respond to external stimuli (e.g., light heat).



All of these studies are directed to create easier and more sophisticated ways to administer therapeutic agents into the body exactly where and when they are needed. Most therapeutic peptides and proteins easily degrade when taken orally and are too unstable to withstand packing in slow-release mechanisms - they all require frequent parenteral injections. Understanding the basics of delivery systems is the key for better medications in the future.

Studies of polymer-cell interaction, with particular emphasis on bioadhesion; development of the basic relationship between polymer structures (molecular and morphological) and living tissue; surface modification for enhancement of cell adhesion, an area of particular importance in the development of oral delivery systems as well as small vascular grafts.

Development of theoretical and experimental procedures to process microcapsules based on biomaterials; processing of polymeric composites based on microencapsulation. A wide range of polymers and polymer blends are investigated, including interpenetrating networks, amorphous, semicrystalline, and liquid crystal polymers.

Grants and Awards

2000 The Eurand Award for Excellence in Research in the Area of Oral Drug Delivery Systems.

1994 Recognition Award for Excellence in Guiding Graduate Student Research. Controlled Release Society—Procter & Gamble. Awarded in Nice, France.

1991-1993 Whitaker Foundation Award.

1985-1987 Bantrell Postdoctoral Fellowship (MIT). A competitive award at MIT in the field of surface science.

1979-1984 Feinberg Fellowship, Weizmann Institute of Science, Israel. A competitive award conferred for graduate research students.

1982 Delek Prize for distinctive research work (Weizmann Institute of Science, Israel).

1973 Distinction Prize for B.Sc. students (Tel Aviv University, Israel).

Affiliations

Controlled Release Society

American Chemical Society (Polymer Division)

American Association for the Advancement of Science

Material Research Society

Biomaterials Society

American Society for Artificial Internal Organs (ASAIO)

Funded Research

Mathiowitz (Principal Investigator) 05/01/2004 to 08/31/2006
Source: Freedom2, LLC
Project Title: "Encapsulation of Dyes, Pigments, and Optically Active Substances for Use in Cell and Tissue Markings"

Project Number: R01 CA100656-01A1 05/1/2004 to 4/30/2006
Source: National Institutes of Health (NIH) Prime University of Louisville Subcontract
Role: Mathiowitz, E. (Investigator), Egilmez, Nejat (PI)
Project Title: "Integrating Innate & Adaptive Immunity in Cancer Therapy"

Mathiowitz (Principal Investigator) 7/1/2001 to 7/31/2005
Source: Spherics, Inc.
Project Title: "Oral Formulation of Large Bioadhesive Drug Delivery System"

Project No.: PHS 2 R01 EB00248-08 Mathiowitz (Principal Investigator) 5/1/1994 to 6/30/2005
Source: National Institutes of Health/National Institute of Biomedical Imaging and BioEngineering (NIH/NIBIB) (Formerly GM47636)
Project Title: "Bioadhesive Microspheres: Comparison in Rats and Pigs"

Project No: CA42278 Egilmez (Principal Investigator) 4/1/2001 to 3/31/2003
Source: Health Research Inc. (NIH Prime)
Role: Mathiowitz, E. (Investigator)
Project Title: "Oxygen and Light Dependency of Photodynamic Therapy"

Project Number: JDFI 4-1999-402 Mathiowitz (Principal Investigator) 4/1/1999 to 3/31/2002
Source: Juvenile Diabetes Foundation
Project Title: "Therapeutic Potential of Erodable Microspheres in IDDM"

Project No.: PHS 1 R01 GM55245-06 Mathiowitz (Principal Investigator) 8/1/1997 to 7/31/2002
Source: National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)
Project Title: "Microspheres for Improved Bioavailability"

Teaching Experience

1992-present Annual speaker in a short course entitled "Formulation Development of Therapeutic Proteins and Drug Delivery Systems For Peptides and Protein Drugs. Controlled Release Systems for Proteins." organized by the American Chemical Society. Chicago, Illinois.

1992-present Teaching Bio 211, "Biomaterials," graduate level course. Biomaterials course is an overview of materials considered biocompatible.

1991-present Teaching Bio 109, "Polymers for Artificial Organs" an undergraduate/graduate level course serving as an introduction to polymer science.

1990 Lecturer in course on microencapsulation. "Microencapsulation and Nanoencapsulation - Process and Pharmaceutical Applications", Sponsored by the Controlled Release Society, Boston, May 14-15, 1990.

1979-1981 Lecturer of chemistry at the "Reali" Gymnasium, Rishon Le Zion, Israel.

1974-1975 Physics and chemistry lecturer in an adult education program at Israel Institute of Biological Research, Nes Ziona, Israel.

Courses Taught

  • Artificial Organs/Biomaterials/Tissue Engineering Seminar (BI0223)
  • Artificial Organs/Biomaterials/Tissue Engineering Seminar (BI0224)
  • Drug and Gene Delivery (BI0211)
  • Polymer Science for Biomaterials (BI0109)

Selected Publications

  • 42. Lavin DM, Harrison, R. MW, Tee LY, Wei KA, Mathiowitz E..,Multifunctional polymeric microfibers with prolonged drug delivery and structural support capabilities.J Biomed Mater Res A. 2012 May 24. (2012)
  • 41. Lavin DM, Harrison MW, Tee LY, Wei KA, Mathiowitz E.,A novel wet extrusion technique to fabricate self-assembled microfiber scaffolds for controlled drug delivery., J Biomed Mater Res A. 2012 May 24 (2012)
  • 43. Lavin DM, Hopkins, E. Mathiowitz," Effects of protein molecular weight on the intrinsic material properties and release kinetics of wet spun polymeric microfiber delivery" Acta Biomaterialia, ACTBIO2333, S1742-7061(12)00372-8, 10.1016/j.actbio.2012.08.00 (2012)
  • 39. Laulicht, B., Nicholas J Gidmark, Anubhav Tripathi, and Edith Mathiowitz., Understanding gastric forces calculated from high-resolution pill tracking. Proc Natl Acad Sci U S A, 2010. 107(18): p. 8201-6. (2010)
  • 40. Bryan Laulicht, Nicholas J Gidmark, Anubhav Tripathi, and Edith Mathiowitz., Localization of magnetic pill. Proc Natl Acad Sci U S A, 2010 (2010)
  • 38. Laulicht, B., et al., Are in vivo gastric bioadhesive forces accurately reflected by in vitro experiments? J Control Release, 2009. 134(2): p. 103-10. (2009)
  • 36. Jacklenec A, Hinkfuss A, Bilgen B, Ciombor DM, Aaron R, Mathiowitz E. Sequential release of bioactive IGF-I and TGF-beta(1) from PLGA microsphere-based scaffolds. Biomaterials 2008; (10): 1518-25. (2008)
  • 34. Furtado S, Abramson D, Burrill R, Olivier G, Gourd C, Bubbers E, Mathiowitz, E. Oral delivery of insulin loaded poly(fumaric-co-sebacic) anhydride microspheres. Int J Pharm. 2008;347(1-2):149-55. (2008)
  • 37. Laulicht B, Cheifetz P, Mathiowitz E, Tripathi A. Evaluation of continuous flow nanosphere formation by controlled microfluidic transport. Langmuir. 2008 Sep 2;24(17):9717-26. 2008 Aug 6. (2008)
  • 33. Morello AP, 3rd, Forbes N, Mathiowitz E. Investigating the effects of surfactants on the size and hydrolytic stability of poly(adipic anhydride) particles. J Microencapsul 2007;24:40-56. (2007)
  • 35. Stacia Furtado, Danielle Abramson, Liat Simhkay, Daniel Wobbekind, Edith Mathiowitz, Subcutaneous delivery of insulin loaded poly(fumaric-co-sebacic anhydride) microspheres to type 1 diabetic rats European Journal of Pharmaceutical and biopharmaceutics, Volume 62 , June 2006, Pages 229–236 (2006)
  • 32. N.A. Rahman, E. Mathiowitz. Localization of bovine serum albumin in double-walled microspheres. Journal of controlled release. 94,163-175, 2004. (2004)
  • 31. CG Thanos, K-P. Yip, and E. Mathiowitz Intestinal Uptake of Polymeric Microspheres In The Rabbit Studies With Confocal Microscopy. Journal of Bioactive and Compatible Polymers, Vol. 19, July 2004: 247-266. (2004)
  • 29. CG C Thanos, Z Liu, J Reineke, E Edwards and E Mathiowitz, Improving Relative Bioavailability of Dicumarol by Reducing Particle Size and Adding the Adhesive Poly (Fumaricˆco-Sebacic) Anhydride. Pharmaceutical Research. Volume 20, Number 7, July 2003; 1093-1100. (2003)
  • 30. C Thanos, Z Liu, M Goddard, J Reineke, N Bailey, M Cross, R Burrill and E Mathiowitz, Enhancing the Oral Bioavailability of the Poorly Soluble Drug Dicumarol with a Bioadhesive Polymer. Journal of Pharmaceutical Sciences. Volume 92, Issue 8, May 2003; 1677-89. (2003)
  • 28. M. Sandor, S Mehta, J Harris, C Thanos, J Marshall, P Weston "Transfection of HEK Cells via DNA-leaded PLGA and P(FASA)" J Drug Targeting, 10, 497-506, 2002. (2002)
  • 27. M. Sandor, J Harris, E Mathiowitz, "A Novel Polyethylene Depot Device for the Study of PLGA Microspheres in Vitro and in Vivo" Biomaterials, 23,4413-4423, 2002. (2002)
  • 26. NA Bailey, M Sandor, M Kreitz, E Mathiowitz, "Comparison of the Enthalpic Relaxation of Poly(Lactide-Co-Glycolide) 50:50 Nanospheres and Raw Polymer" J Applied Polymer Science, 86,1868-1872, 2002. (2002)
  • 25. M.Sandor, NA Bailey, E Mathiowitz "Characterization of polyanhydride microsphere degradation by DSC," Polymers, 43/2, pp279-288, 2001 (2001)
  • 24. C.Santos, B.Freedman, K.Leach, D.Press, M.Scarpulla, E.Mathiowitz, "Polytumaric-co-sebacic anhydride:A Degradation Study as Evaluated by FTIR, DSC, GPC, and X-ray Diffraction". Journal of Controlled Release, 60 (1), 11-22, 1999 (1999)
  • 23. N.Egilmez, Y.Jong, J.Jacobs, C.Santos, E.Mathiowitz, Y.Iwanuma, R.Bankert, "Cytokine immunotherapy of cancer with controlled release biodegradable microspheres in a human tumor xenograft/SCID mouse model, Cancer Immunology Immunotherapy, 1998 Mar; 46(1):21-4. (1998)
  • 22. W. Webber, F. Lago, and E. Mathiowitz, "Characterization of Soluble Salt Loaded Degradable PLA/PG Films and Their Release of Tetracycline," Biomedical Materials Research, 41, 18-29, 1998 (1998)
  • 20. Y. Jong, J. Jacob, K. Yip, G. Gardner, E. Seitelman, M. Whitney, S. Montgomery, and E. Mathiowitz, "Controlled Release of Plasmid DNA," J. of Controlled Releasee 47, 123-134, 1997. (1997)
  • 19. E. Mathiowitz, J. Jacob, Y. Jong, G. Carino, D. Chickering, P. Chaturvedi, C. Santos, K. Vijayaraghavan, S. Montgomery, M. Bassett and C. Morrell, "Biologically Erodable Microspheres as Potential Oral Drug Delivery Systems," Nature 386, 410-414, 1997. (1997)
  • 18. M. Kreitz, W. Webber, P.M.Galletti, and E. Mathiowitz, "Controlled Delivery of Therapeutics from Microporous Membranes I. Fabrication and Characterization of Microporous Polyurethane Membranes Containing Polymeric Microspheres," Biomaterials 18, 597-603, 1997. (1997)
  • 17. Y. Jong, J. Jacob, K. Yip, G. Gardner, E. Seitelman, M. Whitney, S. Montgomery, and E. Mathiowitz, "Controlled Release of Plasmid DNA," J. Controlled Release, In press, 1997. (1997)
  • 15. D. Chickering, J. Jacob and E. Mathiowitz, "Poly(Fumaric-co-Sebacic) Microspheres as Oral Drug Delivery Systems, "Biotechnology and Bioengineering, 52, 96-101, 1996. (1996)
  • 16. K. Pekarek, M. Dyrud, K. Ferrer, Y. Jong, E. Mathiowitz, "In Vitro and In Vivo Degradation of Double-Walled Polymer Microspheres," J. Controlled Release, 40, 169-178, 1996. (1996)
  • 14. D. Chickering, and E. Mathiowitz. "Bioadhesive microspheres: I. A Novel electrobalance-based method to study adhesive interactions between individual microspheres and intestinal mucosa," J. Controlled Release, 34, 251-261, 1995. (1995)
  • 13. Pekarek, J. Jacob and E. Mathiowitz "Double-walled Microspheres for Controlled Drug Release," Nature, 367, 258-260, January 20, 1994. (1994)
  • 12. E. Mathiowitz, J. Jacob, K. Pekarek and D. Chickering, "Morphological characterization of bioerodible polymers. 3. Characterization of the erosion and intact zones in polyanhydrides using scanning electron microscopy," Macromolecules, 26, 6756-6765, 1994. (1994)
  • 11. E. Mathiowitz, M. Kreitz and K. Pekarek. "Morphological characterization of bioerodible polymers. 2. Characterization of polyanhydrides by FTIR," Macromolecules, 26, 6749-6755, 1994. (1994)
  • 10. E. Edelman, E. Mathiowitz, R. Langer and M. Klagsbrum, "Controlled and modulated release of fibroblast growth factor," Biomaterials, 12, 619-626, 1991. (1991)
  • 9. Staubli, E. Mathiowitz and R. Langer, "Sequence distribution and its effect on glass transition temperatures of poly(anhydride-co-imides) containing asymmetric monomers," Macromolecules, 24, 2291-2298, 1991. (1991)
  • 7. E. Ron, E. Mathiowitz, G. Mathiowitz and R. Langer," NMR characterization of erodible copolymers." Macromolecules, 24, 2278-2282, 1991. (1991)
  • 8. Staubli, E. Mathiowitz and R. Langer, "Characterization of hydrolytically degradable amino acid-containing poly(anhydride-co-imides)," Macromolecules, 24, 2283-2290, 1991. (1991)
  • 6. E. Mathiowitz, E. Ron, G. Mathiowitz and R. Langer, "Morphological characterization of bioerodible polymers. I. Crystallinity of polyanhydride copolymers." Macromolecules. 23, 3212-3218, 1990. (1990)
  • 5. E. Mathiowitz and M.D. Cohen, "Polyamide microcapsules for controlled release, V. Photochemical release," Journal of Membrane Science, 40, 67-86 (1989). (1989)
  • 4. E. Mathiowitz and M.D. Cohen, "Polyamide microcapsules for controlled release, IV. Effects of swelling," Journal of Membrane Science, 40, 55-65 (1989). (1989)
  • 3. E. Mathiowitz and M.D. Cohen, "Polyamide microcapsules for controlled release, III. Spontaneous release of azobenzene," Journal of Membrane Science, Vol. 40, 43-54. (1989). (1989)
  • 2. E. Mathiowitz and M.D. Cohen, "Polyamide microcapsules for controlled release, II. Release characteristics of the microcapsules," Journal of Membrane Science, 40, 27-41 (1989). (1989)
  • 1. E. Mathiowitz and M.D. Cohen, "Polyamide microcapsules for controlled release, I. Characterization of the membranes," Journal of Membrane Science, 40, 1-26 (1989). (1989)
  • 21. K. Pekarek Leach, and E. Mathiowitz," Degradation of Double-walled Polymer Microspheres of PLLA and P(CPP:SA) 20:80.I.In vitro Degradation", Biomaterials, 19, 1973-1980, 1998 (1973)
  • Jaklenec A, Mallet, V, Fu K, Lotan N, Langer R. Heparin - poly(lactic acid-co-glycolic acid) hybrid: a multifunctional biomaterial. J Biomed Mater Res, Part A.. ()