Faculty Profile: David Morris, PHD, MA

David Morris, PHD, MA
Professor of Pathology & Laboratory Medicine
Pathology & Laboratory Medicine
Work: +1 401-793-4231
My research is focused on the mechanisms of action of mineralocorticoids and glucocorticoids, not only in the kidney, but also in vascular tissue, with particular attention on their effects relating to sodium retention and hypertension. In addition, we plan to measure the levels of endogenous inhibitors in diseases including essential hypertension, obesity, and ocular hypertension.

Institutions

MH

Research Description

My research is focused on the mechanisms of action of mineralocorticoids and glucocorticoids, not only in the kidney, but also in vascular tissue, with particular attention on their effects relating to sodium retention and hypertension. In addition, my lab is engaged in determining the identity of a variety of adrenally-derived steroid metabolites which provide a source of endogenous inhibitors of the 11beta-hydroxysteroid dehydrogenase isoenzymes, 11b-HSD1 and 11b-HSD2, which regulate the levels of cortisol and cortisone in their target tissues. We plan to measure the levels of these inhibitors in diseases including essential hypertension, obesity, and ocular hypertension.

Grants and Awards

N/A

Affiliations

American Association for the Advancement of Science
American Association of Clinical Chemists
American Heart Association Council for High Blood Pressure Research
The Chemical Society, London
The Endocrine Society, London
National Registry of Clinical Chemists
Rhode Island Society for Diabetes
Society for Drug Research, London
American Society of Hypertension

Funded Research

NIH Grant HL52972, 1994-1997, $394,251
"Novel Endogenous Regulators of Sodium and Hypertension"

NIH Grant DK21404, 1990-1995, $662,066
"Regulation of Metabolism and Action of Aldosterone"

NIH Grant DK 21404, 1987-1989, $198,317
"Regulation of Metabolism and Action of Aldosterone"

National Dairy Council, 1987-1990, $194,803
"Dietary Factors Affecting the Development of Hypertension in SHR"

NIH Grant AM 21404, 1983-1986, $285,100
"Regulation of Metabolism and Action of Aldosterone"

American Heart Association, RI Affiliate, 1983-1985, $35,000
"The Role of Aldosterone and its Metabolites in Hypertension"

NIH Grant AM19179, 1979-1982, $196,660
"Metabolism and Endocrine Action of Aldosterone"

NIH Grant AM 21404, 1979-1982, $201,030
"Regulation of Metabolism and Action of Aldosterone"

NIH Grant AM 19179, 1976-1979, $84,500
"Metabolism and Endocrine Action of Aldosterone"

American Heart Association Grant, 1974-1977, $19,000 per year