Faculty Profile: Kimberly Mowry, PHD

Kimberly Mowry
Kimberly Mowry, PHD
Robin Chemers Neustein Professor of Biomedicine
Molecular Biology, Cell Biology, & Biochemistry
Work: +1 401-863-3636
Research in my laboratory is focused on the problem of polarity, using the Xenopus oocyte as a model system. Our long-term goal is to understand the molecular mechanisms by which informational molecules, such as mRNA and protein, are localized to specified regions of the cell cytoplasm.

Biography

1980 B.A., Biochemistry
University of California at Berkeley, Berkeley, CA

1988 Ph.D., Molecular Biophysics & Biochemistry
Yale University, New Haven, CT
Laboratory of Dr. Joan A. Steitz

1988-1992, Postdoctoral Fellow,
Harvard University, Cambridge, MA
Department of Biochemistry and Molecular Biology
Laboratory of Dr. Douglas A. Melton

1992-1999, Assistant Professor of Biology
Department of Molecular Biology, Cell Biology & Biochemistry
Brown University, Providence, RI

1999-2005, Associate Professor of Biology
Department of Molecular Biology, Cell Biology & Biochemistry
Brown University, Providence, RI

2005-present, Professor of Biology
Department of Molecular Biology, Cell Biology & Biochemistry
Brown University, Providence, RI

Institutions

Bu

Research Description

We have studied the localization of mRNA molecules in the frog oocyte as a model to gain mechanistic insight into how RNA molecules can be targeted to specific regions of the cell cytoplasm to generate spatially restricted gene expression. To piece together the cellular machinery responsible for localization, we are dissecting the RNA-protein interactions leading to Vg1 localization. The focus of these studies is Vg1 RNA, which encodes a signaling molecule and is localized to the vegetal cortex of the oocyte.

Visit our research home page at

http://www.brown.edu/Departments/Molecular_Biology/mowry/

Grants and Awards

Helen Hay Whitney Fellow (1989-1992)
Advanced Postdoctoral-Postresidency Fellow, American Cancer Society (1992)
Salomon Faculty Research Award (1997-1998)
Vartan Gregorian Assistant Professor (1997-1999)
Elizabeth Leduc Award for Excellence in Teaching in the Life Sciences, Brown University (2007)
Robin Chemers Neustein Professor of Biomedicine (2009-present)

Affiliations

Member, Society for Developmental Biology
Member, The RNA Society
Member, American Society for Microbiology

Funded Research

R01GM071049 funded from the NIH to investigate "RNA Localization in Xenopus Oocytes"

Selected Publications

  • Lewis, R.A., Gagnon, J.A. and Mowry, K.L. (2008) PTB/hnRNP I is required for RNP remodeling during RNA localization in Xenopus oocytes. Mol. Cell. Biol. 28:678-686. (2008)
  • Messitt, T.J., Gagnon, J.A., Kreiling, J.A., Pratt, C.A., Yoon, Y.J. and Mowry, K.L. (2008) Multiple kinesin motors coordinate cytoplasmic RNA transport on a subpopulation of microtubules in Xenopus oocytes. Dev. Cell 15:426-36 (2008)
  • Lewis, R.A. and Mowry, K.L. (2007) RNP remodeling during RNA localization. Differentiation 75:507-518. (2007)
  • Lewis, R.A., Kress, T.L., Cote, C.A., Rokop, M., Gautreau, D. and Mowry, K.L. (2004) Conserved and clustered RNA recognition sequences are critical features of signals directing RNA localization in Xenopus oocytes. Mech. Dev. 121: 101-109. (2004)
  • Kress, T.L., Yoon, Y.J. and Mowry, K.L. (2004) Nuclear RNP complex assembly initiates cytoplasmic RNA localization. J. Cell Biol. 165: 203-211. (2004)
  • Chang, P., Torres, J., Lewis, R.A., Mowry, K.L., Houliston, E. and King, M.L. (2004) Localization of RNAs to the mitochondrial cloud in Xenopus oocytes by entrapment and association with endoplasmic reticulum. Mol. Biol. Cell 15: 4669-4681. (2004)
  • Yoon, Y.J. and Mowry, K.L. (2004) Xenopus Staufen is a component of an RNP complex containing Vg1 RNA and kinesin. Development 131: 3035-3045. (2004)
  • Volodina, N. Denegre, J.M. and Mowry, K.L. (2003) Apparent mitochondrial assymetry in Xenopus eggs. Dev. Dyn. 226: 654-62. (2003)
  • Xie, J., Lee, J-A., Kress, T.L., Mowry, K.L. and Black, D.L. (2003) Protein kinase A phosphorylation modulates transport of polypyrimidine tract-binding protein. Proc. Natl. Acad. Sci. USA 100: 8776-8781. (2003)
  • Bubuneko, M., Kress, T.L., Vempati, U.D., Mowry, K.L., and King, M.L. (2002) A consensus RNA signal that directs germ layer determinants to the vegetal cortex of Xenopus oocytes. Dev. Biol. 248: 82-92. (2002)
  • Cote, C.A., Gautreau, D., Denegre, J.M., Kress, T.L., Terry, N.A., and Mowry, K.L. (1999) A Xenopus protein related to hnRNP I has a role in cytoplasmic RNA localization. Mol. Cell 4: 431-437. (1999)