Faculty Profile: Holly Westervelt, PHD

Holly Westervelt, PHD
Assistant Professor of Psychiatry & Human Behavior (Clinical)
Psychiatry & Human Behavior
Work: +1 401-444-4500
Dr. Westervelt's current research interests include olfaction in neurologic/neurodegenerative diseases, the correlation of autopsy findings and antemortem clinical findings in dementia, prodromal Huntington's disease, and cognition in multiple sclerosis.

Institutions

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Research Description

Dr. Westervelt's current research interests include olfaction in neurologic/neurodegenerative diseases, partiicularly the use of odor identification tasks in the differential diagnosis of dementia. She has been funded by Lifespan to create a database containing antemortem neuropsychological data and postmortem brain autopsy data to facilitate clinicopathologic research in dementia. Dr. Westervelt's lab is also responsible for data quality control and training for the cognitive core of a large, international, multi-site study of prodromal Huntington's disease (PREDICT-HD). The PREDICT-HD study is a longitudinal study of HD gene-positive participants, with annual assessments including a cognitive battery, neuroimaging, neurologic motor exam, psychiatric assessment, and functional evaluation. The goal of PREDICT-HD is to identify the most sensitive predictors of onset of HD for use in clinical trials. Lastly, Dr. Westervelt has been involved in several clinical trials of pharmacologic agents to treat cognitive impairment in multiple sclerosis.

Grants and Awards

Nelson Butters Award (best published paper in Archives of Clinical Neuropsychology for 2001), National Academy of Neuropsychology, 2002

Brown Medical School Teaching Recognition Award, 2004

Fellow, National Academy of Neuropsychology, 2010

Warren Alpert Medical School of Brown University Dean's Excellence in Teaching Award, 2011

Funded Research

Current funding:
Title: " Neurobiological Predictors of Huntington's Disease"
Role in Project: Principal Investigator on Subcontract, Data Quality Control
Type of Grant: R01 NS040068-09 (J. Paulsen, PI)
Funding Agency: NINDS
Years funded: 2008-2013
Total Direct costs of subcontract: $199,656

Prior funding:

Title: "Measurement of Olfaction in the Clinical Neuropsychological Exam: Relationship with Memory"
Role in Project: Principal Investigator
Type of Grant: Research Grant
Funding Agency: National Academy of Neuropsychology
Years funded: 2002-2003
Total Direct Costs: $13,113

Title: "The Lifespan Brain Registry: Facilitating Clinicopathologic Correlative Research in Dementia"
Role in Project: Principal Investigator
Type of Grant: Development Grant
Funding Agency: Lifespan Hospitals
Years funded: 2004-2006
Total Direct costs: $21,164

Title: "Interventions to Improve Memory in Patients with MS"
Role in Project: Co-Investigator on Subcontract
Type of Grant: RO1 (L. Krupp, PI)
Funding Agency: National Institute of Child Health and Human Development
Years funded: 2004-2007

Title: Optimizing pathological correlation of diffusion-tensor imaging data
Role in Project: Co-Investigator (S. Correia, PI)
Type of Grant: Research Grant
Funding Agency: Ittleson Foundation
Years funded: 2006-2007

Title: "A Randomized, Double-Blind, Placebo-Controlled, Dose-Titration Study to Assess the Safety, Tolerability, and Efficacy of C105 in Persons with Multiple Sclerosis with Cognitive Impairment"
Role in Project: Co-Investigator on Subcontract
Type of Grant: Research Grant (R. Benedict, PI)
Funding Agency: Cognition Pharmaceuticals LLC
Years funded: 2006-2009

Selected Publications

  • 30. Westervelt, HJ & McLaughlin N (in press). Anosmia. Long entry in Kreutzer JS, DeLuca J, & Caplan B (Eds) Encyclopedia of Clinical Neuropsychology. New York: Springer. (IN PRESS)
  • 29. McCaffrey, RJ, Lynch, JK, & Westervelt, HJ (in press). Clinical Neuropsychology. In Barlow, DH (ed.) Handbook of Clinical Psychology. New York: Oxford University Press. (IN PRESS)
  • 28. Krupp, LB, Christodoulou C, Melville P, Scherl WF, Pai L, Muenz L, He D, Benedict R, Goodman AD, Rizvi S, Schwid SR, Weinstock-Guttman, Westervelt HJ, & Wishart HA. (in press). A multi-center randomized clinical trial of donepezil for memory impairment in multiple sclerosis. Neurology. (IN PRESS)
  • 27. Tremont, G., Miele, A., Smith, M.M., & Westervelt, H.J. (2010). Comparison of verbal memory impairment rates in mild cognitive impairment. Journal of Clinical and Experimental Neuropsychology; 32 (6), 630-636. (2010)
  • 26. Duff K, O'Bryant SE, Westervelt H, Sweet JR, Reynolds CR, van Gorp WG, Tranel D, & McCaffrey RJ. (2009). On becoming a peer reviewer for a neuropsychology journal. Archives of Clinical Neuropsychology, 24, 201-7. (2009)
  • 25. Bruce, JM, Harrington, CJ, Foster, S, Westervelt HJ (2009). Common laboratory values are associated with cognition among elderly inpatients referred for neuropsychological testing. The Clinical Neuropsychologist, 23, 909-25. (2009)
  • 24. Bruce, J.M., McQuiggan, M., Williams, V., Westervelt, H., & Tremont, G. (2008). Burden among spousal and child caregivers of patients with mild cognitive impairment. Dementia and Geriatric Cognitive Disorders. 25 (4), 385-390. (2008)
  • 23. McLaughlin, N, & Westervelt, HJ (2008). Odor identification deficits in frontotemporal dementia: A preliminary study. Archives of Clinical Neuropsychology, 23 (1), 119-23. (2008)
  • 21. Westervelt HJ, Bruce JM, Coon WG, & Tremont G. (2008). Odor identification performance in Mild Cognitive Impairment: No difference among MCI subtypes. Journal of Clinical and Experimental Neuropsychology, 30(2), 151-6. (2008)
  • 22. Bruce, J., Bhalla, R., Westervelt, H., Davis, J., Williams, V., and Tremont, G. (2008). Neuropsychological correlates of self-reported depression and self-reported cognition among patients with mild cognitive impairment. Journal of Geriatric Psychiatry and Neurology. 21 (1), 34-40. (2008)
  • 20. Westervelt, HJ, Carvalho, J, & Duff, K. (2007). Clinical presentation of Alzheimer's disease in patients with and without olfactory deficits. Archives of Clinical Neuropsychology, 22(1), 117-122. (2007)
  • 19. Williams, V.G., Bruce, J.M., Westervelt, H.J., Davis, J.D., Grace, J., Malloy, P.H., & Tremont, G. (2007). Boston Naming performance distinguishes between Lewy Body and Alzheimer's dementias. Archives of Clinical Neuropsychology, 22 (8), 925-31. (2007)
  • 18. Duff, K, Beglinger, LJ, Schultz, SK, Moser, DJ, McCaffrey, RJ, Haase, RF, Westervelt, HJ, Langbehn, DR, Paulsen, JS, & Huntington's Study Group. (2007). Practice effects in the prediction of long-term cognitive outcome in three patient samples: A novel prognostic index. Archives of Clinical Neuropsychology, 22(1), 15-24. (2007)
  • 17. Westervelt, HJ, Brown, LB, Tremont, G, Javorsky, DJ, & Stern, RA (2007). Patient and family perceptions of the neuropsychological evaluation: How are we doing? The Clinical Neuropsychologist, 21(2), 263-73. (2007)
  • 16. Westervelt, HJ, Ruffolo, JS, & Tremont, G (2005). Assessing olfaction in the neuropsychological exam: The relationship between odor identification and cognition in older adults. Archives of Clinical Neuropsychology, 20 (6), 761-9. (2005)
  • 15. Bishop, CL, Temple, RO, Tremont, G, Westervelt, HJ, & Stern, RA. (2003). Utility of the inpatient neuropsychological evaluation in an acute medical hospital. The Clinical Neuropsychologist, 17, 568-473. (2003)
  • 14. Westervelt, HJ, Stern, RA, & Tremont, G. (2003). Odor identification deficits in diffuse Lewy body disease. Cognitive and Behavioral Neurology, 16, 93-99. (2003)
  • 13. Tremont, G, Stern, RA, Westervelt, HJ, Bishop, CL, & Davis, JD (2003). Neurobehavioral functioning in thyroid disorders. Medicine and Health/Rhode Island, 86, 318-322. (2003)
  • 12. Cahn-Weiner, DA, Williams, K, Grace, J, Tremont, G, Westervelt, H, & Stern, RA. (2003). Discrimination of dementia with Lewy bodies from Alzheimer's disease and Parkinson's disease using the Clock Drawing Test. Cognitive and Behavioral Neurology, 16, 85-92. (2003)
  • 11. Westervelt, HJ & McCaffrey, RJ (2002). Neuropsychological functioning in chronic Lyme disease. Neuropsychology Review, 12 (3), 153-177. (2002)
  • 10. Tremont, G, Westervelt, HJ, Javorsky, DJ, Padolanczuk, A, & Stern, RA. (2002). Referring physician's perceptions of the neuropsychological evaluation: How are we doing? The Clinical Neuropsychologist, 16, 551-554. (2002)
  • 8. Duff, K., Westervelt, HJ, McCaffrey, RJ, & Haase, RF. (2001). Practice effects, test-retest stability, and dual baseline assessments with the California Verbal Learning Test in an HIV sample. Archives of Clinical Neuropsychology, 16, 461-476. (2001)
  • 7. McCaffrey, RJ, Westervelt, HJ, & Haase, RF. (2001). Serial neuropsychological assessment with the NIMH AIDS abbreviated neuropsychological battery. Archives of Clinical Neuropsychology, 16, 9-18. (2001)
  • 9. Somerville, J.A., Javorsky, D.J., Tremont, G., Westervelt, HJ, & Stern, R. (2001). A comparison of administration procedures for the Rey-Osterrieth Complex Figure: Flow-charts vs. pen-switching. Psychological Assessment, 13, 299-305. (2001)
  • 6. McCaffrey, RJ, Duff, K, & Westervelt, HJ. (2000). Practitioner's Guide to Evaluating Change with Intellectual Assessment Instruments. New York: Plenum Press. (2000)
  • 5. McCaffrey, RJ, Duff, K, & Westervelt, HJ. (2000). Practitioner's Guide to Evaluating Change with Neuropsychological Assessment Instruments. New York: Plenum Press. (2000)
  • 4. McCaffrey, RJ, Duff, K, Westervelt, HJ, Palav, A, Weber, M, & Haase, RF. (2000). Preliminary serial assessment findings with the Brief NIMH Neuropsychological Battery for HIV Infection and AIDS. NYS Psychologist, 12, 51-54. (invited). (2000)
  • 3. Westervelt, HJ, McCaffrey, RJ, Cousins, JP, Wagle, WA, & Haase, RF. (1997). Longitudinal analysis of olfactory deficits in HIV infection. Archives of Clinical Neuropsychology, 12, 557-565. (1997)
  • 2. McCaffrey, RJ & Westervelt, HJ (1995). Issues associated with repeated neuropsychological assessments. Neuropsychological Review, 5, 203-221. (1995)
  • 1. McCaffrey, RJ, Cousins, JP, Westervelt, HJ, Martynowicz, M, Remick, SC, Szebenyi, S, Wagle, WA, Bottemly, PA, Hardy, CJ, & Haase, RF. (1995). Practice effects with the NIMH AIDS abbreviated neuropsychological battery. Archives of Clinical Neuropsychology, 10, 241-250. (1995)