Faculty Profile: Jeanne McCaffery, PhD

Jeanne McCaffery
Jeanne McCaffery, PhD
Associate Professor of Psychiatry & Human Behavior (Research)
Psychiatry & Human Behavior
Jeanne McCaffery's research interests are twin and family studies and molecular genetics in cardiovascular behavioral medicine. Recent projects include: DNA variation that predicts ability to lose weight with behavioral efforts, genetic predictors of weight regain after weight loss, environmental contributions of socioeconomic status to health behaviors and cardiovascular disease, and DNA variation that predicts depression and physiological responses to psychological stress.

Biography

Jeanne McCaffery, PhD, is an Associate Professor of Psychiatry and Human Behavior at The Miriam Hospital and The Warren Alpert School of Medicine at Brown University. She received her PhD in Clinical and Health Psychology at the University of Pittsburgh and completed her clinical internship at the Brown University Clinical Psychology Training Consortium in 2001. She received The Bruce M. Seyla for Research Excellence from Lifespan Hospitals in 2009 and the Award for Outstanding Contributions to Health Psychology, Junior Division from the American Psychological Association, Division 38 (Health Psychology) in 2011. Her research interests are twin and family studies and molecular genetics in cardiovascular behavioral medicine. Recent projects include: genetic and environmental predictors of weight loss and change in cardiovascular disease risk with weight loss, environmental contributions to health behaviors and cardiovascular disease and genetic variation that contributes to depression among cardiac patients and genetic variation that contribute to the ability to lose weight. She has published over sixty empirical articles and has served a principal investigator or co-investigator on multiple grant awards from the National Institutes of Health.

Institutions

MH

Research Description

Jeanne McCaffery's research interests are twin and family studies and molecular genetics in cardiovascular behavioral medicine. Recent projects include: DNA variation that predicts ability to lose weight with behavioral efforts, genetic predictors of weight regain after weight loss, environmental contributions of socioeconomic status to health behaviors and cardiovascular disease, and DNA variation that predicts depression and physiological responses to psychological stress.

Grants and Awards

Honors

Award for Outstanding Contributions to Health Psychology, Junior Division from the American Psychological Association, Division 38 (Health Psychology), 2011
The Bruce M. Seyla for Research Excellence from Lifespan Hospitals, 2009
Student Travel Award, American Psychosomatic Society, 2001
Student Research Award, American Psychological Association (APA), Division 38 (Health Psychology),2000
Huey Award for Dissertation Research in Clinical Psychology, University of Pittsburgh, 2000
Bassell Award for Excellence in Clinical Psychology Graduate Studies, University of Pittsburgh, 2000
Colavita-Weisburg Award for Excellence in Health Psychology Graduate Studies, University of Pittsburgh, 2000
University of Pittsburgh - Carnegie Mellon University Health Psychology Predoctoral Fellow, University of Pittsburgh, 1999-2000
Cardiovascular Behavioral Medicine Predoctoral Fellow, University of Pittsburgh, 1995-1999

Affiliations

· Member, The Obesity Society, 2005 - present.
· Member, APA, Division 38 (Health Psychology), 2000-present
· Member, American Psychological Association (APA), 1999-present
· Member, American Psychosomatic Society, 1996-present

Funded Research

Active support
DiaComp Feasibility Study Subaward 10/1/13 – 9/30/14
NIH/NIDDK (McCaffery, PI) $65,440 annual
Gene-Environment Interaction in Diabetic Nephropathy: The Look AHEAD Trial.
The purpose of the study is the investigate genetic predictors of diabetic nephropathy among overweight individuals with type 2 diabetes in the Look AHEAD Trial

5 U01 DK056992-13 (Role: Co-Investigator, Wing, PI) 9/30/99 – 7/30/13
NIH/NIDDK $825,735 annual
Study of Health Outcomes of Weight Loss-SHOW Trial
The purpose of this study is to investigate the health outcomes of long-term weight loss and maintenance.

3 U01 DK056992-14S1 (McCaffery, Wing, Co-Principal Investigators) 8/1/09 – 7/31/14
NIH/NIDDK $197,109 annual
Gene x Behavior Interaction in the Look AHEAD Study
The primary goal of this grant is to identify genetic markers that interact with behavioral weight loss treatment to predict the extent of weight loss.

5 U01 CA150387-04 (Role: Co-Investigator, Wing, PI) 9/28/09 – 8/31/14
NIH/NCI $689,582 annual
Increasing Sleep Duration: A Novel Approach to Weight Control
The primary goal of this grant is to translate basic science on sleep and obesity to clinical intervention.

5 R01 DK090043-02 (Role: Principal Investigator) 3/1/11 – 2/28/14
NIH/NIDDK $125,904 annual
Genetic and Behavioral Effects on High-Density Lipoprotein: The Look AHEAD Study
This grant will examine whether genetic markers associated with high-density lipoprotein cholesterol alter the impact of behavioral weight loss intervention on high-density lipoprotein cholesterol.

Completed support
5 P01 HL040962-20 (Role: Co-Investigator, Manuck, PI) 9/7/07 – 1/31/13
NIH/NHLBI $14,825 annual
Biobehavioral Studies of Cardiovascular Disease
This grant is designed to examine the biobehavioral predictors of cardiovascular risk factors and disease.

5 R01 AG018384-09 (Role: Co-Investigator, Lyons, PI) 8/15/08 – 8/31/13
NIH/NIA $12,186 annual
The VETSA Longitudinal Twin Study of Cognition and Aging
The primary goal of this grant is to study genetic and environmental contributions to change in cognitive function.

X01 HG006659 (McCaffery, Huggins, Co-Principal Investigator) 12/1/11 – 11/30/12
NIH/NIDDK Genotyping resource grant
Genetic and Behavioral Effects on High-Density Lipoprotein: The Look AHEAD Study.
This grant is designed to genotype more than 200,000 single nucleotide polymorphism related to cardiovascular disease, serum lipids and related traits in the Look AHEAD cohort.

Department of Psychiatry (Role: Principal Investigator) 9/1/07 – 8/31/09
Brown Medical School $20,000 annual
Endothelial mechanisms of depression in heart disease.
This grant evaluates endothelial mechanisms as predictors of depression in cardiac patients.

P50 CA084719 (Role: Co-Investigator, Niaura PI) 9/30/99-7/31/09
NIH/NCI $25,500 annual
Nicotine Dependence: Phenotype, Endophenotype & Contexts
This grant is designed to examine genetic and environmental predictors of nicotine dependence.

R01 NS052470 (Role: Co-Investigator, Paul, PI) 7/1/07 – 6/30/12
NIH/NINDS $11,955 annual
Neurocognitive markers of cognitive decline
This grant is designed to examine genetic and MRI predictors of cognitive decline.

R01 DK066787-02S2 (Co-Investigator, Wing, PI) 1/1/05 – 12/31/07
NIH/NIDDK $150,000 annual
Long-term weight loss maintenance: functional imaging.
This grant examines fMRI BOLD response in brain regions related reward among people who have lost weight and maintained the weight loss and obese and normal weight controls.

R21 HL077442 (McCaffery, Principal Investigator) 8/01/04-7/31/06
NIH/NHLBI $100,000 annual
Genetic predictors of comorbid depressive symptoms and CAD
The primary goal of this application is to examine candidate genes that may contribute to depressive symptoms, CAD or both.

R01 HL072819 (McCaffery, Principal Investigator) 6/01/04 – 5/31/06
NIH/NHLBI $150,000 annual
SES, health behaviors and early CVD in Vietnam-era Twins
This grant is designed to examine the extent to which socioeconomic status predicts health behaviors and CVD in Vietnam-era Twins.

Teaching Experience

· Course Director, T32 Post-doctoral Seminar Series in Cardiovascular Behavioral Medicine, Centers for Behavioral and Preventive Medicine, Brown Medical School, 2005 – present.

· Seminar Instructor, "Behavioral genetics in behavioral medicine", Brown Clinical Psychology Internship Behavioral Medicine Seminar Series, Brown Medical School, 2001 - present.

· Faculty mentor, Brown Undergraduate Teaching and Research Assistantship awarded to Aimee Two for her project, "STOP! smoking: magazine based intervention to promote smoking cessation among college students", 2004.

· Faculty mentor, Research Internship, Aimee Two, Brown Medical School, 2003-2004. Research training involved the administration of clinical diagnostic interviews and statistical analysis.

· Course Instructor/Teaching Fellow, Undergraduate Abnormal Psychology, University of Pittsburgh, 1999

Selected Publications

  • Manuck, S.B. & McCaffery, J.M. (In press). Gene-environment interaction. Annual Review of Psychology. (IN PRESS)
  • Mezick, E.J., Wing, R.R. & McCaffery, J.M. (In press). Associations of Self-Reported and Actigraphy-Assessed Sleep Characteristics with Body Mass Index and Waist Circumference in Adults: Moderation by Gender. Sleep Medicine. (IN PRESS)
  • Peter, I., Papandonatos, G.D., Belalcazar, L.M., Yang, Y., Erar, B., Jakicic, J.M., Unick, J.L., Balasubramanyam, A., Lipkin, E.W., Delahanty, L.M., Wagenknecht, L.E., Wing, R.R., McCaffery, J.M. & Huggins, G.S. (In press). Genetic Modifiers of Cardiorespiratory Fitness Response to Lifestyle Intervention. Medicine and Science in Sports and Exercise. (IN PRESS)
  • Strohacker, K., McCaffery, J.M., Maclean, P.S., Wing, R.R. (2013) Adaptations of leptin, ghrelin or insulin during weight loss as predictors of weight regain: a review of current literature. International Journal of Obesity. Jun 26. doi: 10.1038/ijo.2013.118. [Epub ahead of print] (2013)
  • McCaffery, J.M., Papandonatos, G.D., Huggins, G.S., Peter, I., Kahn, S.E., Knowler, W.C., Hudnall, G.E., Lipkin, E.W., Kitabchi, A.E., Wagenknecht, L.E., Wing, R.R. (2013) FTO predicts weight regain in the Look AHEAD clinical trial. International Journal of Obesity, Apr 3. doi: 10.1038/ijo.2013.54. [Epub ahead of print] (2013)
  • McCaffery, J.M., Papandonatos, G.D., Huggins, G.S., Peter, I., Erar, B., Kahn, S.E., Knowler, W.C., Lipkin, E.W., Kitabchi, A.E., Wagenknecht, L.E., Wing, R.R. (2013). Human Cardiovascular Disease IBC Chip-Wide Association with Weight Loss and Weight Regain in the Look AHEAD Trial. Human Heredity, 75, 160-174. (2013)
  • Huggins, G.S., Papandonatos, G.D., Erar, B., Belalcazar, L.M., Brautbar, A., Ballantyne, C., Kitabchi, A.E., Wagenknecht, L.E., Knowler, W.C., Pownall, H.J., Wing, R.R., Peter, I., & McCaffery, J.M. (2013). Do Genetic Modifiers of HDL-C and Triglyceride Levels also Modify Their Response to a Lifestyle Intervention in the Setting of Obesity and Type-2 Diabetes Mellitus? The Look AHEAD Study. Circulation: Cardiovascular Genetics; 6(4):391-9. (2013)
  • Strohacker, K., Wing, R.R., McCaffery, J.M. (2013) Contributions of body mass index and exercise habits on inflammatory markers: a cohort study of middle-aged adults living in the USA. BMJ Open. doi:pii: e002623. 10.1136/bmjopen-2013-002623. (2013)
  • Alosco, M.L., Benitez, A., Gunstad, J., Spitznagel, M.B., McCaffery, J.M., McGeary, J.E., Poppas, A., Paul, R.H., Sweet, L.H., & Cohen, R.A. (2013). Reduced memory in Fat Mass and Obesity Associated (FTO) allele carriers among older adults with cardiovascular disease. Psychogeriatrics, 13, 35-40. (2013)
  • Franz, C.E., Spoon, K., Thompson, W., Hauger, R.L., Hellhammer, D.H., Jacobson, K.C., Lupien, S., Lyons, M.J., McCaffery, J., McKenzie, R., Mendoza, S.P., Panizzon, M.S., Ramundo, A., Shahroudi, A., Kremen, W.S. (2013). Adult cognitive ability and socioeconomic status as mediators of the effects of childhood disadvantage on salivary cortisol in aging adults.Psychoneuroendocrinology, 38, 2127-39. (2013)
  • Hassenstab J.J., Sweet L.H., Del Parigi A., McCaffery J.M., Haley A.P., Demos K.E., Cohen R.A., Wing R.R. (2012). Cortical thickness of the cognitive control network in obesity and successful weight loss maintenance: A preliminary MRI study. Psychiatry Res, 202, 77-9. (2012)
  • Keary, T.A., Gunstad, J., Benitez, A., Spitznagel, M.B., McCaffery, J., McGeary, J.E., Poppas, A., Paul, R.H., Sweet, L.H., Cohen, R.A. (2012) TCF7L2 polymorphism and cognitive test performance in cardiovascular disease. Psychogeriatrics, 12, 93-8. (2012)
  • McCaffery, J.M., Marsland, A.L., Strohacker, K., Muldoon, M.F., & Manuck, S.B. (2012). Factor structure underlying components of allostatic load. PLoS One, 7, e47246. (2012)
  • Sweet, L.H., Hassenstab, J.J., McCaffery, J.M., Raynor, H.A., Bond, D.S., Demos, K.E., Haley, A.P., Cohen, R.A., Del Parigi, A. & Wing, R.R. (2012). Brain response to food stimulation in obese, normal weight, and successful weight loss maintainers. Obesity, 20, 2220-5. (2012)
  • Rhee, K.E., Phelan, S., McCaffery, J. (2012). Early determinants of obesity: genetic, epigenetic, and in utero influences. International Journal of Pediatrics, 2012:463850. Epub 2012 May 31. (2012)
  • Hassenstab, J.J., Sweet, L.H., Del Parigi, A., McCaffery, J.M., Haley, A.P., Demos, K.E., Cohen, R.A. & Wing R.R. (2012). Cortical thickness of the cognitive control network in obesity and successful weight loss maintenance: a preliminary MRI study. Psychiatry Research, 202, 77-9. (2012)
  • Saxena R, Elbers CC, … McCaffery, J., … (2012). Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. American Journal of Human Genetics, 90, 410-25. (2012)
  • Keary, T.A., Gunstad, J., Benitez, A., Spitznagel, M.B., McCaffery, J., McGeary, J.E., Poppas, A., Paul, R.H., Sweet, L.H., Cohen, R.A. (2012) TCF7L2 polymorphism and cognitive test performance in cardiovascular disease. Psychogeriatrics. 12, 93-8. (2012)
  • McCaffery J.M., Papandonatos G.D., Peter I., Huggins G.S., Raynor H.A., Delahanty L.M., Cheskin L.J., Balasubramanyam A., Wagenknecht L.E. & Wing R.R. (2012). Obesity susceptibility loci and dietary intake in the Look AHEAD Trial. American Journal of Clinical Nutrition, 95, 1477-86. (2012)
  • Wing R.R., Strohacker K., McCaffery J.M. (2012). Long-term hormonal adaptations to weight loss. Comment on N Engl J Med 2011 Oct 27;365(17):1597-604. New England Journal of Medicine, 366, 382. (2012)
  • Delahanty, L.M., Pan, Q., Jablonski, K.A., Watson, K.E., McCaffery, J.M., Shuldiner, A., Kahn, S.E., Knowler, W.C., Florez, J.C., Franks, P.W. (2012). Genetic Predictors of Weight Loss and Weight Regain After Intensive Lifestyle Modification, Metformin Treatment, or Standard Care in the Diabetes Prevention Program. Diabetes Care. 35, 363-6. (2012)
  • Peter I., McCaffery J.M., Kelley-Hedgepeth A., Hakonarson H., Reis S., Wagenknecht L.E., Kopin A.S. & Huggins G.S.; Genetics Subgroup of the Look AHEAD Study (2012). Association of type 2 diabetes susceptibility loci with one-year weight loss in the look AHEAD clinical trial. Obesity, 20, 1675-82. (2012)