Sickle cell disease is a genetic defect in the protein of the red cell that has far reaching effects, including the brain, lungs, spleen, kidneys, bones, skin, and eyes. With aggressive management we are improving the length and quality of life of children, and now adults with sickle cell disease. We are evaluating neuropsychological functioning, bone function, lung function and how effective our interventions are on these functions and the quality of life of patients and their families.