Faculty Profile: Neal Leleiko, MD, PhD

Neal Leleiko, MD, PhD
Professor of Pediatrics
Work: +1 401-444-8306
Neal LeLeiko's research is currently focused on the natural history of inflammatory bowel disease in children. Most published information on the course of ulcerative colitis and Crohn's disease is decades old. Dr. LeLeiko is the site principal investigator of a multi-centered study aimed at enrolling and following 700 children under 16 years of age across 18 major medical centers to determine the effects of new treatments on the course of IBD.

He is also involved in basic laboratory research on the effect of nutrition on the expression of genes in the gastrointestinal tract.


Neal LeLeiko is a graduate of Brooklyn College and New York Medical College. Following military service he received a PhD in nutritional biochemistry and metabolism from MIT and completed a fellowship in pediatric gastroenterology at Boston Children's Hospital (Harvard Medical School). His academic career has focused on the important role of nutrition in childhood disease and especially diseases of the gastrointestinal tract (IBD and short-gut syndrome) and the liver.



Research Description

Current research is primarily focused on studying the natural history of inflammatory bowel disease in the current therapeutic era. This is a multi-center study involving 18 pediatric gastrointestinal centers in the United States and Canada.

As principal investigator of this site's program, Dr. LeLeiko is responsible for the conduct of the study and meeting the quota of enrolling 60 newly diagnosed children under age 16 into the study.

The principle objective of the current program is to understand the factors influencing various disease-related outcomes.

Grants and Awards

Master of Arts, ad eundem
Brown University (2004)

American Pediatric Society (1997)

Harvey Society (1991)

Society for Pediatric Research (1991)

Solomon Silver Award in Clinical Medicine (1980)

Cor et Manus (Medical School Honor Society) (1971)


American Academy of Pediatrics (Fellow)
Section of Gastroenterology and Nutrition

American Association for the Study of Liver Diseases

American College of Gastroenterology (Fellow)

American Federation of Clinical Research

American Gastroenterological Association

American Pediatric Society

American Society of Gastrointestinal Endoscopy

American Society of Parenteral and Enteral Nutrition

European Society of Pediatric Research (affiliate member)

Gastroenterology Research Group

The Harvey Society

New York Gastroenterology Society

New York Pediatric Society

New York Society of Gastrointestinal Endoscopy

North American Society for Pediatric Gastroenterology and Nutrition
Member, Board Certification Committee
Training and Education Committee (1998-2000)

Society For Pediatric Research

Funded Research

The Natural History of Inflammatory Bowel Disease in Children: The Pediatric IBD Registry
Site P.I
Pediatric Inflammatory Bowel Disease Research Consortium(2002 – Present)

Outcome of intravenous steroid therapy in ulcerative colitis individuals (OSCI)
Site P.I

"OSCCAR: A Novel, Population-based Prospective Inception Cohort of Inflammatory Bowel Disease"
Co-Investigator - (Sands P.I.)
1R21DK078555-01 NIH NIDDK9/2007-9/2008

Ocean State Crohn's and Colitis Area Registry
Co-Investigator (Sands P.I.)
1 UO1 DP000340-03
CDC-CCFA 2007-2009

A Phase 3, Randomized, Open Label, Parallel-group, Multicenter Trial to Evaluate the Safety and Efficacy of Inflixamab (REMICADE) in Pediatric subjects with Moderately to Severely Active Ulcerative Colitis.
Clinical Protocol C0168T72
Site P.I. Centocor
2007 - Present

Retrospective Evaluation of the Safety and Efficacy of Adalimumab in the Treatment of Inflammatory Bowel Disesa in Children (RESEAT)
Site P.I.

Evaluation of the Pharmacokinetics, Safety, Tolerability and Efficacy of Entecavir (ETV) in Pediatic Subjects with Chronic Hepatitis B Virus (HBV) Infection who are HbeAg-positive.
Clinical Protocol AI463028
Site - Data Safety Monitor
Bristol Meyers Squibb