Faculty Profile: Ali Yalcindag, MD

Ali Yalcindag, MD
Associate Professor of Pediatrics (Clinical)
Pediatrics
Work: +1 401-444-8916
My research focuses on a mouse model of atopic dermatitis, a condition characterized by chronic allergic inflammation of skin. Using a mouse model that mimics human atopic dermatitis developed in the laboratory of Dr. Raif Geha at Boston Children's Hospital, I tried to identify the mechanisms by which the immune sytem responds to substances introduced through the skin. Specifically, I studied the role of substances called complements in directing and changing the immune response.

Research Description

Using a mouse model of atopic dermatitis, I studied the role of complement proteins and their recptors in modulating the immune response. I demonstrated that the complement proteinn C3a downregulates the Th2 response to epicutaneously introduced antigens suggesting an important role for complement proteins in T cell polarization. Furthermore, I conducted experiments to show that C3 is important for both Th1 and Th2 immune responses.

Grants and Awards

N/A

Affiliations

American Academy of Pediatrics
American College of Rheumatology
American Medical Association

Funded Research

N/A

Selected Publications

  • Yalcindag A, He Rui Laouini D, Alenius H, He R., Carroll M, Oettgen H, Geha R. The complement component C3 is important for both Th1 and Th2 responses to antigen. J Allergy Clin Immunol 2006 Jun;117(6):1455-61 (2006)
  • Laouini D, Elkhal A, Yalcindag A,et al.COX-2 inhibition enhances the TH2 immune response to epicutaneous sensitization. J Allergy Clin Immunol. 2005 Aug;116(2):390-6. (2005)
  • Kawamoto S, Yalcindag A, Laouini D, Brodeur S, Bryce P, Lu B, Humbles A A, Oettgen H, Gerard C, Geha R. The anaphylatoxin C3a downregulates the Th2 response to epicutaneously introduced antigen. J. Clin Invest 2004 Aug;114(3):399-407. (2004)
  • Laouini D, Kawamoto S, Yalcindag A,et al. Epicutaneous sensitization with superantigen induces allergic skin inflammation. J Allergy Clin Immunol. 2003 Nov;112(5):981-7. (2003)
  • Yalcindag A, Sundel R. Serum Sickness. Book chapter in Current Pediatric Therapy, 17th ed, 2002. (2002)
  • Fisler RE, Liang MG, Fuhlbrige RC, Yalcindag A, Sundel R. Aggressive management of juvenile dermatomyositis results in improved outcome and decreased incidence of calcinosis. Journal of American Academy of Dermatology. 2002; 47. (2002)
  • Ma W, Bryce P, Humbles AA, Laouini D, Yalcindag A, Alenius H, Friend DS, Oettgen HC, Gerard C, Geha RS. CCR3 is essential for skin eosinophilia and airway hyper-responsiveness in a murine model of allergic skin inflammation. J. Clin Invest. 2002; 109: 621-8. (2002)
  • Yalcindag A; Sundel R. Vasculitis in Childhood. Current Opinion in Rheumatology. 2001; Sep 13(5): 422-27. (2001)