Faculty Profile: Daniel Dickstein, M.D.

Daniel Dickstein
Daniel Dickstein, M.D.
Associate Professor; Director PediMIND Program
Dept of Psychiatry & Human Behavior (Primary), Dept of Pediatrics (Secondary)
Work: 401-432-1616
The ultimate goal of my research is to identify bio-behavioral markers--scans and tests--that will make the diagnosis and treatment of psychiatric disorders starting in childhood better--more specific, targeted, accurate, and earlier.

This same approach has revolutionized the war on childhood cancer.

Together, we can make a powerful difference!

In particular, we have ongoing projects involving (a) bipolar disorder, ADHD, and anxiety, (b) teen suicide and self-cutting (non-suicidal self-injury), and (c) autism spectrum disorders.

To learn more, to participate, or to partner in support our work, please go to: http://pedimind.lifespan.org.

Biography

Daniel Dickstein MD leads Bradley Hospital's Pedi-MIND research program, which uses brain imaging techniques, including magnetic resonance imaging (MRI), behavioral measures, and genetic analyses to identify biological and behavioral markers (scans and tests) of psychiatric illness, including bipolar disorder, in children and adolescents. Such markers could help physicians make more accurate diagnoses and improve treatment.

Dr. Dickstein completed his undergraduate and medical studies in Brown University's Program in Liberal Medical Education (PLME), an 8-year combined A.B./M.D. progam. He then completed post-graduate residency training at Brown's triple board program, so named because it combined pediatrics, general psychiatry, and child/adolescent psychiatry into a single, integrated program.

From 2002-2007, Dr. Dickstein was a research fellow and then an assistant clinical investigator at the National Institute of Mental Health's (NIMH) Division of Intramural Research Programs in Bethesda, MD where he began researching brain/behavior interactions underlying pediatric bipolar disorder with Ellen Leibenluft, M.D. and Danny Pine, M.D.

In 2007, Dr. Dickstein returned to join the faculty of the Emma Pendleton Bradley Hospital and the Warren Alpert Medical School of Brown University.

Dr. Dickstein is board-certified in pediatrics, general psychiatry, and child/adolescent psychiatry.

Dr. Dickstein is the recipient of numerous awards, including the NIMH's Richard J. Wyatt, MD Memorial Fellowship Training Award for outstanding scientific accomplishment, NIMH's Mentor of the Year Award, NARSAD's Klerman Award for Outstanding Research in Clinical Brain and Behavior Science, and the American Academy of Child and Adolescent Psychiatry Outstanding Resident Award .

In addition to research, Dr. Dickstein sees outpatients on a limited basis at Bradley Hospital.

Grants and Awards

*NIMH's Richard J. Wyatt, MD Memorial Fellowship Training Award for Outstanding Scientific Sccomplishment

*NIMH's Mentor of the Year Award

*NARSAD's Gerald L. Klerman, M.D. Award for Outstanding Research in Clinical Brain and Behavior Science

*American Academy of Child and Adolescent Psychiatry Outstanding Resident Award

Affiliations

President, RI Council of Child and Adolescent Psychiatry (RICCAP)

Funded Research

1) 5R01MH087513-01 Dickstein DP (PI) 09/30/2009-04/30/2014
NIMH
"Bio-behavioral Markers of Bipolar Conversion"
The goal of this NIMH BRAINS R01 project is to use multi-modal MRI imaging, behavioral tasks, genetic markers, and personal factors to identify bio-behavioral markers of developing full-blown type I BD vs. having sub-syndromal BD not otherwise specified (BD-NOS). We will image 100 young adults followed by the Course and Outcome of Bipolar Youth (COBY) study with BD type I or BD-NOS, plus a newly recruited group of controls.

2) 1R01MH087513-01Deoni S (PI; Dickstein=Consultant) 09/30/2009-06/30/2014
NIMH
Imaging White Matter Maturation During Healthy Brain Development
The goal of this NIMH BRAINS R01 is to quantitatively map the myelination trajectory over the first 5 years of life in a healthy population, and to examine relationships between myelin maturation and cognitive and behavioral development. To achieve this aim, a new method for quantitative myelin imaging, termed mcDESPOT, will first be further develop and optimized for use in pediatric participants. Following 128 infants (3-24 months of age) and 128 toddlers (2-5 years), scanning and age-appropriate psychometric testing will be performed at effective 3 and 6- month intervals, respectively.

3) 1 R01MH092450 Stroud L (PI; Dickstein=Co-I/subcontract PI) 06/06/2011-04/30/2016
NIMH
"HPA and Neural Response to Peer Rejection: Biomarkers of adolescent depression risk."
The goal of this project is to identify neuroendocrine (hypothalamic-pituitary-adrenal axis [HPA]) and neural (resting-state functional connectivity and event-related functional MRI) changes associated with peer rejection in adolescents with depression, and at risk for depression.

4) 1R21MH096850-01 Dickstein DP (PI) 03/08/2012-02/28/2014
NIMH
"COGFLEX: Pilot Translational Intervention of Pediatric Bipolar Disorder"
The goal of this R21 grant is to develop a unique brain-based non-medication treatment for pediatric bipolar disorder using computer-assisted cognitive remediation for reversal learning deficits shown to exist in children and adolescents with bipolar disorder.

Selected Publications

  • Dickstein DP, Rich BA, Roberson-Nay R, Berghorst L, Vinton D, Pine DS, Leibenluft E. Neural Activation During Encoding of Emotional Faces in Pediatric Bipolar Disorder. Bipolar Disorders (In Press 2007). (2007)
  • Dickstein DP, Nelson EE, McClure EB, Grimley ME, Knopf LV, Brotman MA, Rich BA, Pine DS, Leibenluft E. Cognitive Flexibility in Phenotypes of Pediatric Bipolar Disorder. Journal of the American Academy of Child and Adolescent Psychiatry (2007 Mar); 46(3): 341-355. (2007)
  • Dickstein DP, Leibenluft E. Emotion Regulation in Children and Adolescents: Boundaries Between Normalcy and Bipolar Disorder. Development and Psychopathology (2006);18: 1105-1131. (2006)
  • Dickstein DP, Garvey M, Pradella AG, Greenstein D, Sharp W, Castellanos, FX, Pine DS, Leibenluft E. Neurological Examination Abnormalities in Children with Attention Deficit Hyperactivity Disorder and Bipolar Disorder. Biological Psychiatry (2005); 58(7): 517-24. (2005)
  • Dickstein DP, Rich BA, Binnstock AB, Pradella AG, Towbin KE, Pine DS, Leibenluft E. Comorbid Anxiety in Phenotypes of Pediatric Bipolar Disorder. Journal of Child and Adolescent Psychopharmacology (2005); 15(4): 534-48. (2005)
  • Dickstein DP, Milham MP, Nugent AC, Drevets WC, Charney DS, Pine DS, Leibenluft E. Fronto-Temporal Alterations in Pediatric Bipolar Disorder: Results of a Voxel-Based Morphometry Study. Archives of General Psychiatry (2005); 62(7): 734-741. (2005)
  • Dickstein DP, Treland JE, Snow J, McClure EB, Mehta MS, Towbin KE, Pine DS, Leibenluft E. Neuropsychological Performance in Pediatric Bipolar Disorder. Biological Psychiatry (2004); 55(1): 32-39. (2004)