Kevin Bath, Ph.D.
Assistant Professor of Neuroscience (Research)
Bio Med Neuroscience
Work: +1 401-863-1000
My program of research is heavily focused on understanding emotional development and how environmental or pharmacological stressors incurred early in life alter the developmental trajectory of brain centers involved in cognitive and emotional regulation.
Research DescriptionMy lab is focused on understanding emotional development, and the mechanisms through which early life adversity alters brain development to increase susceptibility to later emotional dysfunction. Specifically, I am interested in the role of neurotrophins in brain organization and the impact of early life psychological stress or exposure to prescription drugs on neurodevelopmental outcomes. I use mice as a model system and employ a multidisciplinary approach that relies heavily upon behavioral techniques and integrates genetic, cell & molecular, and anatomical, methods to address this important question. Furthermore, I leverage my expertise in rodent behavior to develop novel translational models of human pathology and collaborate heavily with clinical scientists to investigate the mechanistic basis of sex differences in disease susceptibility and genetic factors that serve to predispose or protect from the effects of early life stressors.
Grants and Awards2007 Travel Award, Society of Biological Psychiatry.
2004 NIMH Training Grant in Neuroethology, Cornell University.
2003 Merck Fellowship, Biology of Developmental Disorders, Princeton University.
2003 Sackler Institute for Developmental Psychobiology Summer Predoctoral Fellowship, Weill Cornell Medical College.
2003 Dallenback Fellowship, Cornell University.
2000 MSIP, Johns Hopkins School of Medicine.
2000 Graduated with Honors, cum laude, Northern Michigan University.
2000 Outstanding Graduating Senior in Psychology, Northern Michigan University.
1999 Jean Rutherford Award (Outstanding Undergraduate in Psychology), Northern Michigan University.
Affiliations2007- Society of Biological Psychiatry.
2005- New York Academy of Sciences.
2001- Association for Chemoreception Sciences.
2001- Society for Neuroscience.
2001- Society for Behavioral Neuroendocrinology.
Funded ResearchBrain and Behavior Research Foundation (NARSAD)- Young Investigator Award (PI: K. Bath) - 7/15/11- 7/14/13
Robert J. and Nancy D. Carney Scientific Innovation Fund- Brown University, Brown Institute for Brain Sciences, (PI: T. Serre, Co-I K.G. Bath).
Mahoney PIlot Award- Brown University, Brown Institute for Brain Sciences, (PI: K.G. Bath, Co-I: M.J. Frank).
- Bath, K.G., Aikins, M.R., and F.S. Lee (2012). BDNF control of SVZ neurogenesis. Developmental Psychobiology. 54(6):578-89. Review. (2012)
- Jeanneteau F.D., Lambert W.M., Ismaili N., Bath K.G., Lee F.S., Garabedian M., and M.V. Chao (2012). Maintenance of hypothalamic CRH by glucocorticoid and BDNF requires the CREB co-activator CRTC2. Proceedings of the National Academy of Sciences, 109(4):1305-10. PMCID: PMC3268297. (2012)
- Bath, K.G., Jing, D.Q., Neeb, C.C., Pattwell, S.S., Chao, M.V., Lee, F.S., and I. Ninan (2012). BDNF Val66Met block fluoxetine-induced enhancement of adult hippocampus plasticity. Neuropsychopharmacology. 37(5):1297-304. PMCID: PMC3306891. (2012)
- Moreno, M.M.*, Bath, K.G.*, Kuczewski, N., Sacquet, J., Didier, A., and N. Mandairon (2012). Action of the noradrenergic system on adult-born cells is required for olfactory learning in mice. Journal of Neuroscience. 32(11):3748-58. PMC Journal - In process. (2012)
- Bath K.G.*, Chuang J.*, Spencer-Segal J.L., Amso D., Altemus M., McEwen B.S., and F.S. Lee. (2012). Variant BDNF (Val66Met) polymorphism contributes to developmental and estrous-stage-specific expression of anxiety-like behavior in female mice. Biological Psychiatry. PMCID: PMC3414635. (2012)
- Magarinos, A.M., Li, C.J., Bath, K.G., Jing, D.Q., Lee, F.S., and B.S. McEwen (2011). Stress-induced hippocampal dendritic remodeling in mice: effect of a partial deficiency in brain-derived neurotrophic factor. Hippocampus. 21(3):253-64. PMCID: PMC2888762. (2011)
- Pattwell, S.S., Bath, K.G., Casey, B.J., Ninan, I., and F.S. Lee (2011). Adolescence and the missing link: Age-dependent impairments in retrieval of fear memories. Proceedings of the National Academy of Sciences, 108(3):1182-7. PMC Journal- in process (2011)
- Spencer-Segal, J.L., Waters, E.M., Bath, K.G., Chao, M.V., McEwen, B.S., and T.A. Milner (2011). Distribution of phosphorylated tyrosine 816 of TrkB receptor in the mouse hippocampal formation depends on sex and estrous cycle stage. Journal of Neuroscience, 31(18); 6780-90. PMCID: PMC3108038. (2011)
- Bath, K.G. and F.S. Lee (2010). Neurotrophic factor control of adult SVZ neurogenesis. Developmental Neurobiology, 70(5):339-49. Review. (2010)
- Casey, B.J., Soliman, F., Bath, K.G., and C.E. Glatt (2010). Imaging genetics and development: challenges and promises. Human Brain Mapping. 31(6):838-51. Commentary. (2010)
- Soliman, F., Glatt, C.E., Bath, K.G., Levita, L., Jones, R., Pattwell, S.S., Jing, D.Q., Tottenham, N., Amso, D., Somerville, L., Voss, H.O., Glover, G., Ballon, D., Liston, C., Teslovich, T., Van Kempen, T., Lee, F.S., and B.J. Casey (2010). Genetic variant BDNF (Val66Met) polymorphism alters learning in mouse and human. Science, 327(5967):863-6. PMCID: PMC2829261. (2010)
- Shmelkov, S.V., Hormigo, A., Jing, D.Q., Bath, K.G., Proenca, C.C., Milde, T., Shmelkov, E.V., Kushner, J., Baljevic, M., Murphy, A.J., Valenzuela, D.M., Gale, N.W., Thurston, G., Yancopoulos, G.D., Ninan, I., Lee, F.S., and S. Raffi (2010). Targeted inactivation of slitrk5 leads to obsessive-compulsive disorder-like behaviors. Nature Medicine, 16(5):598-602. PMCID: PMC2907076. PMCID: PMC2829261. (2010)
- Ninan, I., Bath, K.G., Dagar, K., Perez-Castro, R., Plummer, M.R., Lee, F.S., and M.V. Chao (2010). The BDNF Val66Met polymorphism impairs NMDA receptor-dependent synaptic plasticity in the hippocampus. Journal of Neuroscience, 30(26):838-51. PMCID: PMC2911131. (2010)
- Frielingsdorf, H., Bath, K.G., Soliman, F., Difede, J., Casey, B.J., and F.S. Lee (2010). Variant BDNF Val66Met endophenotypes: implications for post traumatic stress disorder (PTSD). Annals of the New York Academy of Sciences. 1208:150-7. Perspective. (2010)
- Casey, B.J., Glatt, C.E., Tottenham, N., Bath, K.G., Amso, D., Altemus, M., Levitta, L., Soliman, F., Jones, R., Hempstead, B.L., Thomas, K.M., Gunnar, M., Mezey, J., Clark, A., Leon, A.C., Aronson, J., and F.S. Lee (2009). BDNF as a model system for examining gene by environment interactions across development. Neuroscience, 164(1):108-20. Review. (2009)
- Bath, K.G., Voss, H.O., Jing, D., Anderson, S.A., Hempstead, B.L., Lee, F.S., Dyke, J., and D. Ballon (2009). Rapid quantitative phenotyping of genetically engineered mice via magnetic resonance microscopy. Magnetic Resonance Imaging, 27(5):678-85. PMCID: PMC2708118. (2009)
- Carim-Todd, L.*, Bath, K.G.*, Fulgenzi, G., Sudhirkumar, Y., Barrick, C.A., Becker, J., Buckley, H., Dorsey, S. Jing, D.Q., Lee, F.S., and L. Tessarollo (2009). Endogenous truncated TrkB.T1 receptor regulates neuronal complexity and TrkB kinase receptor function in vivo. Journal of Neuroscience, 29(3):678-85. PMCID: PMC2719435. (2009)
- Yu, H., Wang, Y., Pattwell, S., Jing, D.Q., Liu, T., Zhang, Y., Bath, K.G., Lee, F.S., and Z.Y. Chen (2009). Variant BDNF Val66Met polymorphism affects extinction of conditioned aversive memory. Journal of Neuroscience, 29(13):4056-64. PMCID: PMC2668145. (2009)
- Chen, Z.Y., Bath, K.G., McEwen, B.S., Hempstead, B.L., and F.S. Lee (2008). Functional analyses of variant BDNF (Val66Met) polymorphism. Novartis Foundation Symposia, 289:180-187. Review. (2008)
- Bath, K.G., Mandaroin, N., Rajagopal, R., Kapoor, R., Jing, D.Q., Chen, Z.Y., Khan, T., Proenca, C.C., Kraemer, R., Cleland, T.A., Hempstead, B.L., Chao, M.V., and F.S. Lee (2008). Variant BDNF (Val66Met) alters adult olfactory bulb neurogenesis and spontaneous olfactory discrimination. Journal of Neuroscience, 28(10):2383-93. PMCID: PMC2679965. (2008)
- Bath, K.G. and R.E. Johnston (2007). Dominant-subordinate relationships in hamsters: Sex differences in reactions to familiar opponents. Hormones & Behavior, 51(2): 258-64. PMCID: PMC2717792. (2007)
- Bath, K.G. and F.S. Lee (2006). Variant BDNF (Val66Met) impact on CNS structure and function. Cognitive, Affective, and Behavioral Neuroscience, 6(1), 79-85. Review. (2006)
- Chen, Z.Y.*, Jing, D.*, Bath, K.G.*, Ieraci, A., Khan, T., Siao, C.J., Herrera, D.G., Toth, M., Yang, C., McEwen, B.S., Hempstead, B.L., and F.S. Lee, (2006). Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior. Science, 314(5796):140-3. PMCID: PMC1880880. (2006)
- Prosen, C.A., Bath, K.G., Vetter, D.E., and B.J. May (2000). Behavioral assessment of sensory function in transgenic mice. Journal of Behavioral Neuroscience Methods, 97(1):59-67. (2000)