Faculty Profile: Satyan Kalkunte, M.Pharm, Ph.D

Satyan Kalkunte, M.Pharm, Ph.D
Instructor in Pediatrics (Research)
Bio Med Pediatrics
Work: +1 401-274-1122
A focus of Dr. Kalkunte's research has been to develop in vitro and animal models for preeclampsia, understand mechanisms for target development, and to screen potential molecules that can prevent the onset of disease. His recent work suggests that preeclampsia is a disorder of protein misfolding and amyloidogenic aggregates. Apart from translational therapeutics and diagnostics, his long-term research interest is to understand factors influencing the developmental origins of chronic disease

Biography

A focus of Dr. Kalkunte's research in collaboration with Dr. Sharma has been to develop in vitro and animal models for preeclampsia, understand mechanisms for target development, and to screen potential molecules that can prevent the onset of disease. Using patient's serum as a "blueprint", Dr. Kalkunte has established novel in vitro and in vivo models for preeclampsia. Using proteomic approaches to identify causative factors in serum, Dr. Kalkunte's work has contributed to identification of dysregulated transthyretin that suggest that preeclampsia is likely disorder of protein misfolding and amyloidogenic aggregates. In addition, Dr. Kalkunte's work has contributed to the understanding of the role of hCG, Tregs, heme, angiogenesis, and complement factors in preeclampsia. His complementary work on enviormental toxicants in preterm birth and polyhydramnios is well appreciated. Together, his long-term goal is to propel translational therapeutics and diagnostic tools from bench to bedside and pursue developmental origins of chronic disease.

Affiliations

American Association of Advancement of Science (AAAS), USA
Sigma Xi,The Scientific Research Society, USA
Society of Experimental Biology & Medicine (SEBM),USA
New York Academy of Sciences (NYAS), USA
American Society of Reproductive Immunology (ASRI), USA
American Association of Pharmaceutical Scientists(AAPS), USA

Funded Research

NIH-National Center for Research Resources (5P20RR018728-10) & National Institute of General Medical Sciences (8 P20 GM103537-10)-PI: James Padbury
Lead Investigator Pilot Project I: Satyan Kalkunte, COBRE for Perinatal Biology
Period: 08/01/2011-07/31/13
The major goals of this project is to develop in vivo models of preeclampsia, understand the interplay of angiogenesis, apoptosis, and immunology at the maternal-fetal interface that can lead to identification of causative biomarkers and potential targets. This would further help develop strategies for new therapeutic interventions by defining how several of these events impact fetal and newborn development.

Selected Publications

  • Kalkunte S, Neubeck S, Norris W, Kostadinov S, Hoang DV, Ahmed A, Shaikh Z, Padbury JP, Berg G, Olofsson A, Markert U, Sharma S. Transthyretin is dysregulated in preeclampsia and its native form prevents the onset of disease in mice. 2012 (Under Revision) (2012)
  • Lai Z, Kalkunte S, Sharma S. A critical role of IL-10 in limiting hypoxia-induced preeclampsia-like disease in mice. Hypertension. 57(3),505-14 2011. (2011)
  • Kalkunte S, Norris W, Friedman J, Lai Z, Kurtis K, Lim K, Boij R, Padbury J, Matthiesen L, Sharma S. Sera from preeclampsia patients elicits symptoms of human disease in mice and provides a basis for an in vitro predictive assay. Am J Pathol 177, 2387-2398, 2010 (2010)
  • Tewari N, Kalkunte S, Murray DM, Sharma S. The water channel aquaporin 1 is a novel molecular target of polychlorinated biphenyls for in utero anomalies. J Biol Chem 284 (22),15224-32, 2009 (2009)
  • Kalkunte S, Mselle TF, Norris WE, Wira CR, Sentman CL, Sharma S. VEGF C facilitates immune tolerance and endovascular activity of human uterine NK cells at the maternal-fetal interface. J Immunol 182 (7), 4085-92, 2009 (2009)
  • Kalkunte S, Lai Z, Tewari N, Chichester CO, Romero R, Padbury J, Sharma S. In-vitro and in-vivo evidence for lack of endovascular remodeling by third trimester trophoblasts. Placenta. 29, 871-878, 2008 (2008)
  • Kalkunte S, Singh AP, Chaves FC et al. Antidepressant and anti-stress activity of GC-MS characterized lipophillic extracts of Ginkgo biloba leaves. Phytother Res. 21(11), 1061-65, 2007 (2007)
  • Satyan KS, Jaiswal AK, Ghosal S, Bhattacharya SK. Anxiolytic activity of Ginkgolic Acid – conjugates from Indian Ginkgo biloba Linn Psychopharmacology, 136 (2), 148-152, 1998 (1998)
  • Satyan KS, Jaiswal AK, Ghosal S, Bhattacharya SK. Effect of Ginkgolic acid conjugates on the brain monoamines and metabolites in rats. Biogenic Amines 13(2), 143–151, 1997 (1997)
  • Jaiswal AK, Upadhyay SN, Satyan KS,Bhattacharya SK. Behavioral effects of prenatal and postnatal under nutrition in rats. Ind J Exp Biol 34, 1216–1219, 1996 (1996)