Faculty Profile: Catherine Gordon, MD, MSc

Catherine Gordon, MD, MSc
Professor of Pediatrics
Bio Med Pediatrics
Work: 401-444-4712
Research Summary

Dr. Catherine Gordon's work is directed at developing new approaches to prevent bone loss in at-risk patients by defining the lifestyle variables that affect the development of peak bone mass. She is seeking to identify factors that contribute to bone loss in healthy children and adolescents, as well as in those with such disorders as anorexia nervosa, inflammatory bowel disease, and cystic fibrosis. She is particularly interested in the influence of nutrition on hormones that affect bone development, such as adrenal and gonadal androgens, in this age group. In a related line of research, she is evaluating peripheral quantitative computed tomography (PQCT) as modalities for measuring bone density in adolescents.

Research Description

Dr. Gordon is Director of the Division of Adolescent Medicine at Hasbro Children's Hospital. She holds a joint appointment in the Brown University Departments of Pediatrics and Orthopedics. She has received independent funding from NIH, Department of Defense, and private foundations to lead a clinical research team at Hasbro Children's Hospital and Brown University.
Ongoing studies include:
-Strategies to prevent bone loss in women with anorexia nervosa;
-Mechanisms of bone loss in young adults with cystic fibrosis and inflammatory bowel disease;
-Risk factors associated with stress fractures in female athletes;
-Nutritional and environmental factors associated with subclinical vitamin D deficiency and rickets;
-Peripheral quantitative computed tomography (PQCT) as a tool for measuring bone density in children and adolescents;
-Skeletal phenotype in children with the rare disease, progeria

Grants and Awards

"Best of Boston," Pediatric Endocrinology, 2007 â€ââ'¬Å" 2012;
"Best of Providence," 2013; selected by peers through Best Doctors of America, Inc.

NC State University Distinguished Alumna Award, North Carolina State University, 2008

Estherann Grace Faculty Teaching Award, Division of Adolescent/Young Adult Medicine, Boston Children's Hospital, 2010

A. Clifford Barger Excellence in Mentoring Award, Harvard Medical School, 2011

Affiliations

Professor of Pediatrics, Warren Alpert Medical School of
Brown University, 2012 - Present

Adjunct Faculty, Yale University School of Nursing, 2013 ̢蠉â'¬â"¢ present

Associate Professor of Pediatrics, Harvard Medical School, 2006 â€ââ'¬Å" 2012

Assistant Professor of Pediatrics, Harvard Medical School, 2001-2006

Instructor in Pediatrics, Harvard Medical School, 1998-2000

Funded Research

Other Support for Dr. Catherine Gordon
ACTIVE

American Pediatric Society and the Society for Pediatric Research 05/01/11-04/30/14 0.36 cal
APS-SPR $15,112
Short Term Research Training in Pediatrics for Medical Students
To provide funding support for the training of 30 first year medical students in pediatric research throughout the United States.
Role: Principal Investigator

R01 AR060829-01 (Gordon) 08/01/11 – 05/31/15 3.6 cal
NIH/NIAMS $230,316
Effect of Adrenal and Gonadal Hormones on Bone Marrow and Appendicular BMD
To evaluate the effect of combined therapy with dehydroepiandrosterone and estrogen/progestin on appendicular bone density and marrow composition in adolescent girls with anorexia nervosa.
Role: Principal Investigator

R01 HL106160-01 (Sacheck) 06/01/11 -11/30/14 0.6 cal
NIH/SRG/KNOD $5,306
Impact of Vitamin D Supplementation on Cardiometabolic Risk in Schoolchildren
To examine the effects of various vitamin D dosages on levels of vitamin D as well as on cardiometabolic risk factors in children.
Role: Co-Investigator

5-U01-HD040533 (Wilson) 03/01/11 – 02/29/16 0.36 cal
$6,294 (sub only)
NIH/NICHD through a subcontract with the University of Alabama at Birmingham
Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Coordinating Center
The goal of the ATN network is to conduct research, both independently and collaboratively, in HIV infected and HIV-at-risk pre-adolescents, adolescents, and young adults up to the age of 25.
Role: Co-Investigator

Progeria Research Foundation (Kleinman) 07/01/13 – 06/30/14 0.6 cal
$12,851 (sub only)
An Open Label Phase II Trial of Zoledronic Acid, Pravastatin, and Lonafarnib (SCH66336) for Patients with Hutchinson-Gilford Progeria Syndrome (HGPS) and Progeroid Laminopathies
Clinical trial for children with the rare disease Hutchinson-Gilford Progeria Syndrome.
Role: Co-Investigator

RFA-HD-12-207 (Arpadi) 07/01/10 – 06/30/17 0.6 cal
NIH/NICHD $14,088
Bone Health in Perinatally HIV-infected South African Children on Antiretrovirals
To examine the bone health of HIV-infected children and adolescents in resource constrained settings.
Role: Co-Investigator

PENDING:

The Daily D Study: Vitamin D Supplementation, 25OHD, and Diabetes Risk in Children (Sacheck)
NIH 04/01/2014 – 03/31/2017 0.6 cal
To examine the effects of varying vitamin D dosages on levels of vitamin D as well as on diabetes risk factors in children.
Role: Co-Investigator

OVERLAP: None

Selected Publications

  • DiVasta AD, Feldman HA, Beck TJ, LeBoff MS, Gordon CM. Does hormone replacement normalize bone geometry in adolescents with anorexia nervosa? J Bone Miner Res 2013 (in press). (2013)
  • DiVasta A, Feldman HA, Gordon CM. Vertebral fracture assessment in adolescents and young women with anorexia nervosa: A case series. J Clin Densitom. 2013 (in press) (2013)
  • Topor LS, Melvin P, Giancaterino C, Gordon CM. Factors associated with low bone density in patients referred for assessment of bone health. Int J Pediatr Endocrinol. 2013 Feb 6;2013(1):4. (2013)
  • Putman M, Gordon CM, Feldman HA, Pitts S, Milliren C. A randomized clinical trial of vitamin D supplementation in healthy adolescents. J Adolescent Health. 2013;52(5):592-8. (2013)
  • GT. The male reproductive system in classic galactosemia: cryptorchidism and low semen volume. J Inherit Metab Dis. 2013 [Epub ahead of print]. (2013)
  • Gubbels CS, Welt CK, Dumoulin JC, Robben SG, Gordon CM, Dunselman GA, Rubio-Gozalbo E, Berry ()