Faculty

Belenky, Peter
Lab website
Assistant Professor of Molecular Microbiology and Immunology

We study the response of the microbiome and isolated bacteria and fungi to external stress such as antimicrobial agents. This work is particulary pressing because unlike at any other time in human history, we are currently exposed to a wide array of natural and artificial antimicrobial agents in the form of antibiotics, chemical disinfectants, chemotherapeutic agents and others. Understanding how these extracellular stressors affect the microbiome will provide critical biological insight into the development of dysbiosis, disease, and antibiotic resistance and will lead to novel therapeutic methodologies. Relying on recent advances in high-throughput DNA and RNA sequencing we are studying the effects of antimicrobial mechanisms that lead to improved antimicrobial tolerance and the development of resistance.
Peter_Belenky@brown.edu

Bennett, Richard
Lab website

Associate Professor of Medical Science
My laboratory is interested in understanding the biology of the human pathogen Candida albicans. C. albicans is a yeast that grows in the human gastrointestinal tract and is usually harmless to humans. However, in some cases, Candida can cause localized infections in healthy individuals and even life-threatening systemic (bloodstream) infections in immunocompromised individuals. The focus of the laboratory is to understand how Candida acts as a pathogen in humans.
Richard_Bennett@brown.edu

Biron, Christine
Esther Elizabeth Brintzenhoff Professor of Medical Science
Research in Professor Biron's laboratory is directed at understanding the cellular and cytokine mechanisms regulating immune defenses. There is a particular interest in the responses to acute viral infections and links between innate and adaptive immunity. Basic pathways regulating natural killer (NK) and T cells are being defined. Focus includes regulation of the signal transducers and activators of transcription (STATs).
Christine_Biron@Brown.edu

Brossay, Laurent
Chair in Molecular Microbiology & Immunology and Professor of Medical Science
The research in our laboratory is directed at understanding the molecular mechanisms controlling the activation of both NK and NK T cells. These two subsets of cells respond quickly to a stimulus and their activation can determine the outcome of an immune response.
Laurent_Brossay@brown.edu

Bungiro, Richard
Senior Lecturer in Biology
Richard_Bungiro@brown.edu

Campbell, Andrew G.
Associate Professor of Medical Science
The research program of the lab involves understanding the fundamental structure and function relationships of RNases H with the long term goals of a) unmasking novel nucleic acid metabolic functions associated with the enzymes and b) understanding their placement in the replicative life cycle of the pathogenic protozoan Trypanosoma brucei. Trypanosomes are amongst the earliest branching eukaryotes and are the models in which RNA editing and trans-splicing were initially discovered. Accordingly, they are well suited for our studies.
Andrew_Campbell@Brown.edu

de Graffenried, Christopher
Assistant Professor of Molecular Microbiology and Immunology (Research)
We study the replication of the cytoskeleton in T. brucei, the causative agent of African trypanosomiasis (sleeping sickness) in humans. We have shown that the Polo-like kinase homolog in T. brucei (TbPLK) is essential for the inheritance of the parasite's single flagellum, which is necessary for motility and viability.  We focus on understanding how TbPLK affects flagellar inheritance by regulating the duplicaton and segregation of a suite of cytoskeletal organelles that position the flagellum.
Christopher_deGraffenried@Brown.edu

Elias, Jack
Dean of the Division of Biology and Medicine
Jack_Elias@brown.edu

Jamieson, Amanda
Assistant Professor of Molecular Microbiology and Immunology
The main focus of my laboratory is understanding infectios and non-infectious diseases of the lung, specifically how multiple lung diseases interact and influence each other.  Using clinically relevant model systems we examine the impact of the lung microbiome on pulmonary diseases, alterations of the immune response during viral/bacterial coinfection, and the alteration of epithelial cells and tissue repair mechanisms during pulmonary infections, coinfections, and other lung diseases.
Amanda_Jamieson@Brown.edu

Knopf, Paul M.
Charles A. and Helen B. Stuart Professor Emeritus of Medical Science
Prof. Knopf's career interest has been in protein biosynthesis, initially in general but primarily in immunoglobulins and their role as antibodies in humoral immune reponses. Since joining the Brown faculty, he has studied protective antibody responses to worm and protozoan parasitic infections (vaccine development against schistosomiasis and malaria), responses to antigens in the brain (autoimmunity), and most recently the role of complement C3d in the induction of the T-dependent antibody response.
Paul_Knopf@Brown.edu

Lee, Chun Guen
Professor of Molecular Microbiology and Immunology (Research)
My current research interest focuses on defining the molecular and immunologic mechanism regulating airway and alveolar remodeling that includes emphysema, fibrosis and lung cancer. Recently our laboratory, in collaboration with Dr. Elias, made a significant progress in defining the role of chitinase-like protein (CLP) Chi3l1/YKL-40 in the pathogenesis of allergic inflammation, airway remodeling, and lung injury. Our laboratory also has been intensely working to define in vivo role and mechanism of chitotriosidase, TGF-beta1 and other mediators that regulate the development of lung fibrosis by generation and characterization of gene-specific null and transgenic mice.
Chun_Lee@brown.edu

Miah, Shahjahan
Investigator in Molecular Microbiology & Immunology
Shahjahan Miah's research focuses on Natural Killer cells inhibitory receptors trafficking and signaling. Inhibitory receptor cell surface expression is modulated by a variety of factors. Inparticular, I am interested in KLRG1 and Ly49 trafficking at steady state or following ligand engagement.
Shahjahan_Miah@brown.edu

Mylonakis, Eleftherios
Chief, Infectious Diseases Division and Professor of Medicine
Dr. Mylonakis is recognized for his research on the study of microbial pathogenesis and host responses. His studies have included clinical and laboratory studies and the use of mammalian and invertebrate model hosts. These surrogate hosts fill an important niche in pathogenesis research and provide us with a unique opportunity to identify novel antimicrobial compounds and study basic, evolutionarily conserved aspects of microbial virulence and host response. His investigations have identified novel virulence factors, cross kingdom pathogen-pathogen interactions, novel agents and evolutionarily conserved traits that are involved in host virulence and immune responses during fungal infection. Taken in their totality, these results indicate that a common, fundamental set of molecular mechanisms is employed by pathogens against a widely divergent array of metazoan hosts. His research has resulted in >200 peer-reviewed scientific articles. Mylonakis, has edited five books on infectious diseases and is the founding editor-in-chief of Virulence.

Rice, Louis
Chair of Medicine, Joukowsky Professor of Medicine
LRice@lifespan.org

Shank, Peter
Professor Emeritus of Medical Science
Peter Shank received his BS from Cornell University and his Ph.D. from The University of North Carolina at Chapel Hill. He was a postdoctoral fellow at UCSF working with Michael Bishop and Harold Varmus on retroviruses. He joined the Brown faculty in 1978 and has worked with both avian and human retroviruses. He has published extensively on the molecular biology of retroviruses and has served on editorial boards and numerous NIH review panels.
Peter_Shank@Brown.edu

Wands, Jack
Professor of Medicine
Jack Wands directs the Liver Research Center, a newly constructed 13,000-sq. ft. facility that emphasizes studies relating to the molecular biology of liver diseases.
Jack_Wands_MD@Brown.edu

Vaishnava, Shipra
Assistant Professor of Molecular Microbiology and Immunology
Nearly 100 trillion bacteria reside in our gut, yet, we rarely elicit a harmful immune and inflammatory response against them. How is such a peaceful coexistence achieved? Work in my lab focuses on studying the interactions between microbes and the host at the molecular level that ensures this host-microbe mutualism. We use germ-free mouse models in combination with broad array of genetic, cell biological and biochemical approaches to explore the complex interactions between intestinal bacteria and the immune system. The projects in the lab are focused on understanding 1) the role of immunity in regulating host-microbe interaction at the mucosal surface, 2) the composition of microbial communities closest to the mucosal surface and how they are perturbed during infection and inflammation and 3) the molecular mechanisms by which dietary cues regulate immune responses in the gut to bacteria. 
Shipra_Vaishnava@brown.edu

Zhou, Yang
Assistant Professor of Molecular Microbiology and Immunology (Research)
My primary research interests are directed towards understanding the immunopathogenesis of lung injury and repair. I have interrogated the roles of a chitinase-like protein and its receptors in a variety of lung diseases including asthma, chronic obstructive pulmonary disease (COPD), and pulmonary fibrosis. My future research plans are aimed at dissecting the common mechanisms that underlie the pathogenesis of pulmonary fibrosis, specifically the role of intracellular receptor trafficking pathways in disease progress. My long-range research goals are to identify the immune and cellular responses that mediate lung injury and repair responses and to identify specific molecular targets that can be targeted in the treatment of related disorders.
Yang_Zhou@brown.edu