Our Research

An Overview

Human diseases are complex, multistage processes that evolve over years or even decades. Numerous factors - endogenous, environmental, and genetic - can contribute to or modify these disease processes by acting alone or in concert. Traditionally, pathologists established the diagnosis and determined prognostic criteria for disease using morphological and biochemical techniques.  Modern experimental pathologists integrate classical morphological techniques with new approaches.  With the use of powerful new tools for quantitative imaging and molecular analysis of human tissue, pathology is entering an exciting new era of research.

The integration between biology and medicine at Brown University and its partner institutions provides a unique environment for pathologists to develop interdisciplinary translational research initiatives. 

 

 Laser capture microdissection allows scientists to dissect individual cells or groups of cells using a computer-guided laser, and to isolate these individual cells to study their characteristics

 

Faculty in the Department of Pathology and Laboratory Medicine are trained in the cellular, biochemical, and molecular mechanisms of disease that provide the foundation for basic, translational, and clinical research.  Basic research programs focus on environmental health and disease including cancer, reproductive and genetic toxicology, and neurodegenerative disease.  Translational and clinical research initiatives include nanotechnology, diagnostic and prognostic markers for cancer, developmental and perinatal pathology, medical screening and prenatal genetic testing, transgenic models of human disease, infectious diseases, host responses to malaria and schistosomiasis, clotting disorders, and transfusion medicine. 

 

Whole slide digital imaging allows scientists to capture the entire image on a microscopic slide as a single digital image

 

 

These interdisciplinary research initiatives include faculty in the School of Engineering and the Departments of Clinical Neurosciences, Medicine, Surgery, Pediatrics, and Obstetrics and Gynecology at Brown University.

 

 

DNA microarrays, or “chips”, is an array of attached DNA fragments in a defined array on a solid support.  This allows scientists to study thousands of individual DNA segments at the same time and to predict how individual patients respond to personalized cancer therapy.