Dissecting Genes and Environment in Aging

Leader:  David Rand – Bio Med Ecology & Evolutionary Biology

Aging is a complex phenomenon with both genetic and environment components. Research indicates that key aging mechanisms are shared across the animal kingdom. One of the most consistent means of delaying aging is the through dietary or caloric restriction.  Identifying the genes and pathways that regulate this process is an important goal for aging research.  Using Drosophila strains carrying different mitochondrial and nuclear genetic variants, students will investigate how specific dietary manipulations interact with these genetic mutations to regulate lifespan, health span and resistance to stress.  We will conduct a large longevity experiment and additional health-span and stress resistance assays to identify the conditions that promote long and healthy lives.

Aging 2%