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Welcome to the Peti Laboratory

The focus of the Peti laboratory is to understand the molecular Wolfgang Peti, PhD: Associate Professor of Medical Science & Associate Professor of ChemistryWolfgang Peti, PhD: Associate Professor of Medical Science & Associate Professor of Chemistrybasis of essential biological processes. Signaling cascades direct information transmission and, in turn, function in processes as diverse as memory and muscle movement. These cascades are mediated by a network of highly specific and tightly regulated protein:protein interactions, including those made by serine/threonine kinases and serine/threonine phosphatases.

Our long-term goal is to achieve an in-depth understanding of signaling networks with a special focus on serine/threonine phosphatase signaling, by using chemical, biochemical, biophysical, structural biology, especially NMR spectroscopy and X-ray crystallography, and in vivo technologies.

Proteins are the main functional building blocks of our body and signaling information, how we sense and react to our environment, is communicated in the cell by phosphorylation of specific residues of these proteins. A vast, integrated network of proteins ensures that only specific proteins are phosphorylated and/or dephosphorylated at certain times to guarantee full function. If this regulation, especially in the brain, is disrupted, it often leads to disease, resulting in dramatically altered behavior, development and interaction. It is my overall scientific aim to translate our understanding of these protein signaling cascades into high resolution 3-dimensional pictures. This will enable us to study the protein:protein interactions that mediate this signaling in detail at atomic resolution. Our technique of choice for these studies is Nuclear Magnetic Resonance (NMR) spectroscopy. Learn more about the Peti Lab's NMR techniques.

Peti Laboratory in the Brown University News