Nuclear Magnetic Resonance (NMR) Spectroscopy

Our technique of choice for the Peti Laboratory is Nuclear Magnetic Resonance (NMR) spectroscopy, which is best known in day-to-day life as magnetic resonance imaging (MRI), its low resolution equivalent. The 3-dimensional models we elucidate using NMR will allow us to not only understand how these proteins mediate and regulate signaling, but also to develop small molecules, most often used as drugs, which modulate the activity of these proteins. Therefore, we will be able to either enhance or disrupt such protein:protein interactions, and therefore enhance or disrupt complete signaling pathways, critical for curing diseases. Only by developing these detailed pictures we will be able to influence these pathways individually, ensuring less signaling cross-talk and therefore higher selectivity of drugs with fewer risks.