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Brown, hospitals strike IP agreements

Brown University’s Technology Ventures Office will help manage and market select biomedical discoveries and inventions generated by researchers in the Lifespan heath care system. Brown has also expanded its IP management and commercialization services to all of the hospitals within Care New England Health System. The two agreements create a single place to find life science innovations from Brown and its affiliated hospital groups.

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Could lubricin stop OA in damaged joints?
Gregory Jay:

Researchers from Brown and Rhode Island Hospital have shown that joint fluid lacking in a protein called lubricin fails to adequately lubricate joints. That lack of lubrication leads to increased friction in the joint and eventually to the death of cartilage cells. The work also shows that lubricin protects cartilage and could serve as a means to reduce the risk or even prevent osteoarthritis.

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CO2 could produce valuable chemical cheaply
A possible use for excess carbon:

Researchers at Brown and Yale have demonstrated a new “enabling technology” that could use excess carbon dioxide to produce acrylate, a valuable commodity chemical involved in the manufacture of everything from polyester cloth to disposable diapers.

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Misregulated genes may have big autism role
Implicated in rare forms of autism, two genes may have wider role:

A genetic pathway involving proteins in the endosomes of cells appears to be misregulated in the brains of children with autism, according to a newly published statistical analysis in the journal Molecular Psychiatry. Previously the genes were shown to cause rare forms of the disease but the new study suggests they have a wider role.

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Sepsis drug fails to help in clinical trial
A major clinical problem, largely unknown to patients:

Sepsis kills hundreds of thousands of Americans and more people around the world annually. While doctors have made progress, they don’t yet have a medicine specific to the condition. Many had hoped a drug called Eritoran would be that remedy, but phase 3 clinical trial results newly published in the Journal of the American Medical Association show it was no better than a placebo.

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Tunkel named dean for medical ed

Dr. Allan R. Tunkel, chair of medicine at Monmouth Medical Center and professor of medicine at Drexel University College of Medicine, has been appointed associate dean for medical education at The Warren Alpert Medical School of Brown University. On July 15, Tunkel will succeed Dr. Phil Gruppuso, professor of pediatrics, who has served eight years in the post. Tunkel will supervise curriculum planning, evaluation, and management for the four-year medical program and Brown’s Program in Liberal Medical Education.

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Under California: An ancient tectonic plate
Mostly gone, not forgotten:

The Isabella anomaly — indications of a large mass of cool, dehydrated material about 100 kilometers beneath central California — is in fact a surviving slab of the Farallon oceanic plate. Most of the Farallon plate was driven deep into the Earth’s mantle as the Pacific and North American plates began converging about 100 million years ago, eventually coming together to form the San Andreas fault.

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Commentary by Prof Ulrich Heintz: A Higgs boson or the Higgs boson?
Ulrich Heintz:

Last July physicists at CERN announced they had found a particle that looked a lot like the elusive Higgs boson, a particle thought to give mass to some elementary particles. After poring over two and a half times more data than was available in July, CERN announced today that their particle is still a spot-on match for the Higgs. Brown physicists David Cutts, Ulrich Heintz, Greg Landsberg, and Meenakshi Narain are active participants in the Higgs search. Gerald Guralnik is one of the theorists who first predicted the particle’s existence in 1964.

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Costs of War' Project: 190,000 lives, $2.2 trillion
Reckoning the costs of the Iraq War:

More than 190,000 people have been killed in the 10 years since the war in Iraq began. The war will cost the U.S. $2.2 trillion, including substantial costs for veterans care through 2053, far exceeding the initial government estimate of $50 to $60 billion, according to a new report by scholars with the "Costs of War" project at Brown University's Watson Institute for International Studies. The 10th anniversary of the U.S. invasion of Iraq is March 19, 2013. 

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Political strife undermines HIV treatment
Displacement can be deadly:

Among other tragedies in countries with HIV epidemics, political violence can have the additional long-term consequence of an increase in viral resistance to treatment and HIV treatment failure, say the authors of a new paper in AIDS Reviews. The researchers, who have studied post-strife treatment failure and resistance in Kenya, argue that officials and health care providers need to study and prepare for how violence disrupts antiretroviral treatment and complicates the epidemic. 

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Lunar impacts created seas of molten rock
Melting on a massive scale	:

A new analysis of data from NASA’s Lunar Orbiter Laser Altimeter (LOLA) shows that molten rock may have been present on the Moon more recently and for longer periods than previously thought. Differentiation — a settling out of rock layers as liquid rock cools — would require thousands of years and a fluid rock sea at least six miles deep.

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Weinstock wins dermatology honor

Dr. Martin Weinstock, professor of dermatology and epidemiology in the Warren Alpert Medical School of Brown University, has won the Lila and Murray Gruber Cancer Research Award, the highest scientific honor of the American Academy of Dermatology. On March 3, 2013, Weinstock, who practices at the Providence VA Medical Center, gave a plenary talk at the AAD’s annual meeting in Miami Beach: “Public Health Science will cut Melanoma Deaths in Half." Weinstock is the first epidemiologist to win the award in its 41-year history.

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