Hyaline membrane disease
This disease, associated with surfactant deficiency in premature infants, is characterized by eosinophilic hyaline membranes
lining the airspaces, bronchioles, and alveolar ducts. There is little inflammatory reaction. Hyaline membranes are composed
of necrotic debris from type II pneumocytes mixed with fibrin. Similar membranes can be seen in older patients, who are
not surfactant deficient, such as term newborns if they suffer diffuse alveolar damage; e.g. in perinatal asphyxia with shock lung.
1 minute clinical correlation