Rebecca Page | X-ray Crystallography
Rebecca Page, Principal InvestigatorDepartment of Molecular Biology, Cell Biology and BiochemistryMy laboratory uses X-ray crystallography , NMR spectroscopy and small angle X-ray scattering (SAXS) in combination with biochemistry and genetics to understand the molecular basis of protein function, with a particular interest in understanding how bacterial signaling proteins regulate biolfim formation and antibiotic resistance, how targeting proteins direct the activity of ser/thr phosphatases and how dual specificity and tyrosine phosphatases regulate MAPK function. Biofilms, persistence and antibiotic resistance
PP1 holoenzymes in the nucleus
Regulation of MAPKs by phosphatases
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Breaking News
Graduate Student Dana Lord recieved her PhD (5/2014). Congratulations Dr. Lord! Undergraduate Robin Rolander was awarded the prestigous Brown Univeristy UTRA award (4/2014). Graduate Student Dana Lord received a travel award and was also invited to give a lecture at the 2013 American Crystallographic Association meeting in Hawaii (8/2013). Our review, the 'Structural Basis of PP1 Regulation and Specificity' is the FEBS Journal most downloaded paper in 2013. Outreach: The 5th annual Protein Science Workshop and Lecture, a collaboration between the Page lab and the Biotechnology Certificate Program at CCRI was held. Recent Publications
For a full publication list, click here. Choy et al (2014) Understanding the antagonism of retinoblastoma protein dephosphorylation by PNUTS provides insights into the PP1 regulatory code. PNAS 111: 4097-4102. Peti & Page (2013) Molecular Basis of MAPK Regulation Protein Science, 22: 1698-1710. Collaborator WebSites
Wolfgang Peti, Ph.D., Brown University. Lutz Tautz, Ph.D., The Burnham Institute. Thomas Wood, Ph.D, Pennsylvania State University. Useful Links
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