Loucks is using a 50-year follow-up of the New England Family Study to explore how conditions during pregnancy and early life may impact epigenetic alterations and aging processes that could subsequently appear in midlife as atherosclerosis, type 2 diabetes, adiposity and cognitive decline. During this project, Loucks will assess the aging processes in 500 of the Collaborative Perinatal Project (CPP) participants born in 1959-1966 to explore the life course effects on aging.