Research

The Darling Lab conducts basic science and translational investigations involving mesenchymal stem cells. Areas of emphasis include single-cell elastic and viscoelastic properties (mechanical biomarkers) and live-cell gene expression analysis (molecular beacons). Ongoing studies are looking at the issue of cellular heterogeneity and its effect on stem cell differentiation. Additional work related to these topics and others are pursued through collaborators at Brown University, Rhode Island Hospital, and other research institutions.


Major research tracks in the Darling Lab include:

Single-cell mechanical biomarkersSingle-cell mechanical biomarkers Live-cell, gene expression analysisLive-cell, gene expression analysis Tissue- and lineage-specific cell enrichment via mRNA biomarkersTissue- and lineage-specific cell enrichment via mRNA biomarkers
Age-related disparities in MSC regeneration capacityAge-related disparities in MSC regeneration capacity Mechanical and biological heterogeneity in differentiating stem cellsMechanical and biological heterogeneity in differentiating stem cells