Laboratory Resources

Laboratories of Molecular Medicine (LMM)

LMM The Page laboratory is housed in a new 105,000 sq. ft. research laboratory, the Laboratories of Molecular Medicine, LMM, with more than 750 sq. feet of individual wet laboratory space plus an additional room for computation work and a separate data collection facility. The laboratories in LMM are open-lab-space facilities, allowing close interaction with the adjunct structural biology and molecular biology groups at Brown University. LMM also houses a number of Core Facilities, including the newly established Structural Biology Core Facility (SBCF), the Proteomics and Biophysical Characterization Facility and the Genomics Core Facility. Shared biophysical equipment includes a Microcal iTC200, Microcal VP-DSC, Jasco J-815 CD, Fluor-Max, LTQ Oribitrap Velox and AKTAprime Plus.

State-of-the-Art Crystallography Instrumentation

Akta PurifierThe newly established Structural Biology Core Facility (SBCF) houses the new X-ray crystallography, small angle X-ray scattering and NMR instrumentation. It is directed by Dr. Michael Clarkson, Assistant Professor Research, who has more than 15 years of experience in NMR spectroscopy, SAXS and crystallography techniques. In July 2012, a Rigaku 'Ultimate Home Lab' system was installed, which includes an FRE+ Superbright microfocus generator coupled with the Varimax-HF Arc)Sec confocal optics, with a Saturn 944HG CCD detector and an ACTOR crystal mounting robot on one port for crystal diffraction and a BioSAXS-100 SD-Kratky Camera System on the second port for solution scattering. Additional crystallography equipment in the laboratory includes an Art Robbins Phenix nanoliter crystallization robot, a CrysCam imaging system and both ALS and Uni Pucks for automated crystal screening and data collection both at Brown and at Synchrotrons. The SBCF also houses the NMRs, which includes a Bruker AVANCEII 500 MHz spectrometer with a TCI HCN z-gradient cryoprobe and, as of 11/2012, a Bruker AVANCEII 850 MHz spectrometer.

New NMR Instrumentation to arrive 11/2012

Akta Purifier

The SBCF also houses the NMR spectrometers, which includes a Bruker AVANCEII 500 MHz spectrometer with a TCI HCN z-gradient cryoprobe and, as of 11/2012, a Bruker AVANCEII 850 MHz spectrometer which will also have a TCI HCN z-gradient cryoprobe .